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10058-F4

Cat. No. 4406 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inhibits c-Myc-Max dimerization
化学名： 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
纯度： ≥99% (HPLC)
说明书
引用文献
评论 (1)
文献 (3)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 10058-F4

10058-F4 is a cell permeable c-Myc-Max dimerization inhibitor. Inhibits proliferation, induces apoptosis and arrests cells in G0/G1 in rat1a-c-Myc cells. Also reduces tumor growth in vivo. In lymphoma cells, 10058-F4 decreases glucose uptake and expression of glycolysis-associated genes and reduces cell viability.

化合物库 for 10058-F4

10058-F4 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for 10058-F4

分子量 249.35
公式 C12H11NOS2
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 403811-55-2
PubChem ID 1271002
InChI Key SVXDHPADAXBMFB-JXMROGBWSA-N
Smiles O=C(NC(S2)=S)/C2=C\C1=CC=C(CC)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 10058-F4

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 24.93 100
ethanol 4.99 20

制备储备液 for 10058-F4

以下数据基于产品分子量 249.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.01 mL 20.05 mL 40.1 mL
5 mM 0.8 mL 4.01 mL 8.02 mL
10 mM 0.4 mL 2.01 mL 4.01 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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参考文献 for 10058-F4

参考文献是支持产品生物活性的出版物。

Yin et al (2003) Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene 22 6151 PMID: 13679853

Huang et al (2006) A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia. Exp.Hematol. 34 1480 PMID: 17046567

Guo et al (2009) Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice. Cancer Chemother.Pharmacol. 63 615 PMID: 18509642

Broecker-Preuss et al (2017) Regulation of glucose uptake in lymphoma cell lines by c-MYC- and PI3K-dependent signaling pathways and impact of glycolytic pathways on cell viability J.Transl.Med. 15 158 PMID: 28724379

If you know of a relevant reference for 10058-F4, please let us know.

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10058-F4 的评论

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works perfectly.
By Anonymous on 07/28/2019
分析类型： In Vitro
种属： Human

Used the compound for studying the anti-cancer properties. The compound 10058-F4, strongly induced caspase‐3‐dependent apoptosis in pre‐B ALL cells.

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Pathways for 10058-F4

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.