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16673-34-0 NLRP3i

Cat. No. 6774 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： NLRP3 inflammasome inhibitor
别名： JC121
化学名： N-[2-[4-(Aminosulfonyl)phenyl]ethyl]-5-chloro-2-methoxybenzamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 16673-34-0 NLRP3i

16673-34-0 NLRP3i is a NLRP3 inflammasome inhibitor. Inhibits formation of NLRP3 inflammasome and IL-1β release in LPS and ATP-stimulated mouse macrophages and cardiomyocytes in vitro. Inhibits NLRP3 activation in mouse acute myocardial infarction and peritonitis models without affecting plasma glucose levels. Glyburide synthetic intermediate.

化合物库 for 16673-34-0 NLRP3i

16673-34-0 NLRP3i is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for 16673-34-0 NLRP3i

分子量 368.84
公式 C16H17ClN2O4S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 16673-34-0
PubChem ID 85542
InChI Key KVWWTCSJLGHLRM-UHFFFAOYSA-N
Smiles COC1=C(C(NCCC2=CC=C(S(N)(=O)=O)C=C2)=O)C=C(C=C1)Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 16673-34-0 NLRP3i

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 18.44 50

制备储备液 for 16673-34-0 NLRP3i

以下数据基于产品分子量 368.84。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.42 mL 27.11 mL 54.22 mL
2.5 mM 1.08 mL 5.42 mL 10.84 mL
5 mM 0.54 mL 2.71 mL 5.42 mL
25 mM 0.11 mL 0.54 mL 1.08 mL

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产品说明书 for 16673-34-0 NLRP3i

分析证书/产品说明书
化学品安全技术说明书

参考文献 for 16673-34-0 NLRP3i

参考文献是支持产品生物活性的出版物。

Marchetti et al (2014) A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse. J.Cardiovasc.Pharmacol. 63 316 PMID: 24336017

Fulp et al (2018) Structural insights of benzenesulfonamide analogues as NLRP3 inflammasome inhibitors: design, synthesis, and biological characterization. J.Med.Chem. 61 5412 PMID: 29877709

If you know of a relevant reference for 16673-34-0 NLRP3i, please let us know.

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关键词: 16673-34-0 NLRP3i, 16673-34-0 NLRP3i supplier, NLRP3, inflammasome, inhibitors, inhibits, ischemia, reperfusion, injury, glyburide, impurity, intermediate, acute, myocardial, infarction, AMI, JC121, Inflammasomes, 6774, Tocris Bioscience

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