187-1, N-WASP inhibitor

Name: 187-1, N-WASP inhibitor
Brand: Tocris Bioscience
SKU: 2067

Cat. No. 2067 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2067 has been discontinued.

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说明： N-WASP inhibitor; inhibits actin assembly

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for 187-1, N-WASP inhibitor

Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP₂)-stimulated actin assembly (IC₅₀ ~ 2 μM) but does not directly inhibit actin polymerization.

技术数据 for 187-1, N-WASP inhibitor

分子量	1784.13
公式	C₉₆H₁₂₂N₁₈O₁₆
序列	KFPFFPQ KFPFFPQ (Modifications: Phe-2 = D-Phe, Pro-3 = D-Pro, Phe-4 = D-Phe, Pro-6 = D-Pro, Cyclized)
储存	Desiccate at -20°C
CAS Number	380488-27-7
PubChem ID	44405676
InChI Key	PHTIQAVQWWOKNF-RNEDXEELSA-N
Smiles	NCCCC[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@H]2CCCN2C(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@H]2CCCN2C(=O)[C@@H](CC2=CC=CC=C2)NC1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for 187-1, N-WASP inhibitor

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 187-1, N-WASP inhibitor

参考文献是支持产品生物活性的出版物。

Suetsugu et al (2001) Identification of another actin-related (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP. J.Biol.Chem. 276 33175 PMID: 11432863

Prehoda and Lim (2002) How signaling proteins integrate multiple inputs: a comparison of N-WASP and cdk2. Curr.Opin.Cell Biol. 14 149 PMID: 11891112

Peterson et al (2001) A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc.Natl.Acad.Sci.USA 98 10624

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关键词: 187-1, N-WASP inhibitor, 187-1, N-WASP inhibitor supplier, inhibitors, inhibits, actin, assembly, neural, Wiskott-Aldrich, syndrome, protein, Actin, 2067, Tocris Bioscience

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