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Description: Selective inhibitor of myosin II ATPase activity. Non-cytotoxic version of (±)-Blebbistatin (Cat. No. 1760)
Chemical Name: (3aS)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-(4-nitrophenyl)-4H-pyrrolo[2,3-b]quinolin-4-one
Purity: ≥98% (HPLC)
Biological Activity for para-Nitroblebbistatin
para-Nitroblebbistatin is a selective inhibitor of Myosin II ATPase activity (IC50 = 15 μM). It is a non-fluorescent, photostable, non-cytotoxic and non-phototoxic derivative of (±)-Blebbistatin (Cat. No. 1760).
(S)-(-)-Blebbistatin (Cat. No. 1852) also available.
Technical Data for para-Nitroblebbistatin
| M. Wt | 337.34 |
| Formula | C18H15N3O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1621326-32-6 |
| PubChem ID | 102361739 |
| InChI Key | KAUXNLHXGQGFOS-GOSISDBHSA-N |
| Smiles | O[C@@]12C(N(C3=CC=C(C=C3)[N+]([O-])=O)CC2)=NC4=CC=C(C)C=C4C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for para-Nitroblebbistatin
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.87 | 50 |
Preparing Stock Solutions for para-Nitroblebbistatin
The following data is based on the product molecular weight 337.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.93 mL | 29.64 mL | 59.29 mL |
| 2.5 mM | 1.19 mL | 5.93 mL | 11.86 mL |
| 5 mM | 0.59 mL | 2.96 mL | 5.93 mL |
| 25 mM | 0.12 mL | 0.59 mL | 1.19 mL |
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Product Datasheets for para-Nitroblebbistatin
References for para-Nitroblebbistatin
References are publications that support the biological activity of the product.
Gollapudi et al (2021) Two classes of myosin inhibitors, para-nitroblebbistatin and mavacamten, stabilize β-cardiac myosin in different structural and functional states. J.Mol.Biol. 433 167295 PMID: 34627791
Képiró et al (2011) para-Nitroblebbistatin, the non-cytotoxic and photostable myosin II inhibitor Angew.Chem Int.Ed.Engl. 53 8211 PMID: 24954740
Värkuti et al (2016) A highly soluble, non-phototoxic, non-fluorescent blebbistatin derivative. Sci.Rep. 31 26141 PMID: 27241904
If you know of a relevant reference for para-Nitroblebbistatin, please let us know.
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Keywords: para-Nitroblebbistatin, para-Nitroblebbistatin supplier, Selective, inhibitors, inhibits, myosin, II, ATPase, photostable, non-cytotoxic, non-phototoxic, Myosin, 8804, Tocris Bioscience
Citations for para-Nitroblebbistatin
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