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1A-116

Cat. No. 6701 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Rac1 inhibitor; blocks Rac1-P-Rex1 interaction
化学名： N-(3,5-Dimethylphenyl)-N'-[2-(trifluoromethyl)phenyl]guanidine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 1A-116

1A-116 is a Rac1 inhibitor. Reduces intracellular Rac1-GTP levels and blocks Rac1-P-Rex1 interaction in vitro. Exhibits no effect on GTPase activity of closely related Cdc42. Displays antiproliferative, anti-invasive and pro-apoptotic activity in several cancer cell lines. Exhibits antimetastatic activity in vivo. Also restores antiproliferative effects of Tamoxifen (Cat. No. 6342) in resistant breast cancer cell.

许可信息

Sold under license from Romikin S.A.

化合物库 for 1A-116

1A-116 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for 1A-116

分子量 307.31
公式 C16H16F3N3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1430208-73-3
PubChem ID 71543346
InChI Key DVIJFJSZZNOTLP-UHFFFAOYSA-N
Smiles CC1=CC(NC(NC2=C(C(F)(F)F)C=CC=C2)=N)=CC(C)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 1A-116

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.73 100
ethanol 30.73 100

制备储备液 for 1A-116

以下数据基于产品分子量 307.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.54 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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参考文献 for 1A-116

参考文献是支持产品生物活性的出版物。

Cardama et al (2014) Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines. Anticancer Agents Med.Chem. 14 840 PMID: 24066799

Gonzalez et al (2017) Pharmacological inhibition of Rac1-PAK1 axis restores tamoxifen sensitivity in human resistant breast cancer cells. Cell Signal. 30 154 PMID: 27939839

Cabrera et al (2017) Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines. Oncotarget. 8 98509 PMID: 29228706

If you know of a relevant reference for 1A-116, please let us know.

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关键词: 1A-116, 1A-116 supplier, rac1, gtpase, inhibitors, inhibits, tamoxifen, resistance, breast, cancer, Rho, 6701, Tocris Bioscience

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