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2-Cl-IB-MECA

Cat. No. 1104 13 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Highly selective A3 agonist
化学名： 1-[2-Chloro-6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-β-D-ribofuranuronamide
纯度： ≥98% (HPLC)
说明书
引用文献 (13)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 2-Cl-IB-MECA

2-Cl-IB-MECA is a high affinity and extremely selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively. Exhibits high selectivity over the Na+-independent adenosine transporter.

许可信息

Sold with the permission of the NIH, US Patent 08/091,109

技术数据 for 2-Cl-IB-MECA

分子量 544.74
公式 C18H18ClIN6O4
储存 Desiccate at +4°C
纯度 ≥98% (HPLC)
CAS Number 163042-96-4
PubChem ID 3035850
InChI Key IPSYPUKKXMNCNQ-PFHKOEEOSA-N
Smiles O[C@@H]1[C@@H]([C@](NC)=O)O[C@@H](N(C=N4)C2=C4C(NCC3=CC(I)=CC=C3)=NC(Cl)=N2)[C@@H]1O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 2-Cl-IB-MECA

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 100

制备储备液 for 2-Cl-IB-MECA

以下数据基于产品分子量 544.74。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.84 mL 9.18 mL 18.36 mL
5 mM 0.37 mL 1.84 mL 3.67 mL
10 mM 0.18 mL 0.92 mL 1.84 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

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产品说明书 for 2-Cl-IB-MECA

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for 2-Cl-IB-MECA

参考文献是支持产品生物活性的出版物。

Jacobson (1998) Adenosine A3 receptors: novel ligands and paradoxical effects. TiPS 19 184 PMID: 9652191

Kim et al (1994) 2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors. J.Med.Chem. 37 3614 PMID: 7932588

Schaick et al (1996) Hemodynamic effects of histamine release elicited by the selective adenosine A3 receptor agonist 2-Cl-IB-MECA in conscious rats. Eur.J.Pharmacol. 308 311 PMID: 8858305

If you know of a relevant reference for 2-Cl-IB-MECA, please let us know.

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关键词: 2-Cl-IB-MECA, 2-Cl-IB-MECA supplier, selective, A3, agonists, Receptors, adenosines, 2ClIBMECA, Adenosine, 1104, Tocris Bioscience

13 篇 2-Cl-IB-MECA 的引用文献

引用文献是使用了 Tocris 产品的出版物。 2-Cl-IB-MECA 的部分引用包括：

Angelantonio et al (2015) Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R. Sci Rep 9 409 PMID: 26528137

Ren et al (2015) An adenosine A3 receptor agonist inhibits DSS-induced colitis in mice through modulation of the NF-κB signaling pathway. J Neurosci 5 9047 PMID: 25762375

Kan et al (2012) Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway. J Virol 86 10338 PMID: 22787201

Montinaro et al (2012) Adoptive immunotherapy with Cl-IB-MECA-treated CD8+ T cells reduces melanoma growth in mice. PLoS One 7 e45401 PMID: 23028986

Rosito et al (2012) CXCL16 orchestrates adenosine A3 receptor and MCP-1/CCL2 activity to protect neurons from excitotoxic cell death in the CNS. Neoplasia 32 3154 PMID: 22378888

Morello et al (2011) NK1.1 cells and CD8 T cells mediate the antitumor activity of Cl-IB-MECA in a mouse melanoma model. Am J Cancer Res 13 365 PMID: 21472141

Corriden et al (2013) Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes. Biochim Biophys Acta 14 726 PMID: 23817552

Bhanu et al (2008) Inhibition of erythroblast growth and fetal hemoglobin production by ribofuranose-substituted adenosine derivatives. J Pharmacol Exp Ther 1782 504 PMID: 18586086

Iannone et al (2014) Adenosine limits the therapeutic effectiveness of anti-CTLA4 mAb in a mouse melanoma model. EMBO Rep 4 172 PMID: 24660106

Vincenzi et al (2013) Pulsed electromagnetic fields increased the anti-inflammatory effect of A2A and A3 adenosine receptors in human T/C-28a2 chondrocytes and hFOB 1.19 osteoblasts. PLoS One 8 e65561 PMID: 23741498

Jinka et al (2011) Season primes the brain in an arctic hibernator to facilitate entrance into torpor mediated by adenosine A(1) receptors. J Neurosci 31 10752 PMID: 21795527

Man et al (2003) Alteration of the purinergic modulation of enteric neurotransmission in the mouse ileum during chronic intestinal inflammation. Br J Pharmacol 139 172 PMID: 12746236

Germack and Dickenson (2004) Characterization of ERK1/2 signalling pathways induced by adenosine receptor subtypes in newborn rat cardiomyocytes. Br J Pharmacol 141 329 PMID: 14751870

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