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说明： D2-like antagonist; displays some D4 selectivity
化学名： 2-Chloro-11-(4-methylpiperazino)dibenz(Z)[b,f]oxepin maleate
生物活性 for 2-CMDO
2-CMDO is a dopamine D2-like receptor antagonist that displays some selectivity for D4 receptors (Ki values are 0.54 and 2.5 nM for D4 and D2 receptors respectively).
技术数据 for 2-CMDO
| 分子量 | 442.9 |
| 公式 | C19H19ClN2O.C4H4O4 |
| 储存 | Store at RT |
| CAS Number | 24140-98-5 |
| PubChem ID | 71296946 |
| InChI Key | OOHVXDUNWCMZCI-WLHGVMLRSA-N |
| Smiles | [H]OC(=O)\C=C\C(=O)O[H].CN1CCN(CC1)C1=CC2=C(OC3=C1C=C(Cl)C=C3)C=CC=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for 2-CMDO
参考文献 for 2-CMDO
参考文献是支持产品生物活性的出版物。
Phillips et al (1994) Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptane analogues of cloz. to DA and serotonin receptors. J.Med.Chem. 37 2686 PMID: 8064797
Phillips et al (1995) Binding of 5H-dibenzo[a,d]cycloheptane and dibenz[b,f]oxapin analogues of cloz. to DA and serotonin receptors. J.Med.Chem. 38 708 PMID: 7861418
Zawilska et al (2003) L-745,870 suppresses the nighttime serotonin N-acetyltransferase activity in chick retina: in vivo evidence for agonist activity at D4-DA receptors. J.Neural Transm. 110 219 PMID: 12658371
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关键词: 2-CMDO, 2-CMDO supplier, D2-like, antagonists, Displays, D4, selectivity, Dopamine, Non-Selective, Receptors, dopaminergic, 2-Chloro-11-(4-methylpiperazino)dibenz[b,f]oxepin, maleate, Non-selective, 0782, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.