2-Furoyl-LIGRLO-amide

Name: 2-Furoyl-LIGRLO-amide
Brand: Tocris Bioscience
SKU: 3015
Rating: 5 (1 reviews)

Cat. No. 3015 3 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent and selective PAR₂ agonist

纯度： ≥95% (HPLC)

说明书

引用文献 (3)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 2-Furoyl-LIGRLO-amide

2-Furoyl-LIGRLO-amide is a potent and selective PAR₂ receptor agonist (pD₂ = 7.0). Causes a dose-dependent relaxation of murine femoral arteries.

技术数据 for 2-Furoyl-LIGRLO-amide

分子量	777.96
公式	C₃₆H₆₃N₁₁O₈
序列	LIGRLX (Modifications: Leu-1 = 2-Furoyl-Leu, X = Orn & C-terminal amide)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	729589-58-6
PubChem ID	10395438
InChI Key	OSKIRYSKGDEIOG-WTWMNNMUSA-N
Smiles	[H]N([C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN)C(N)=O)C(=O)C1=CC=CO1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 2-Furoyl-LIGRLO-amide

溶解性	Soluble to 1 mg/ml in water

产品说明书 for 2-Furoyl-LIGRLO-amide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 2-Furoyl-LIGRLO-amide

参考文献是支持产品生物活性的出版物。

McGuire et al (2004) 2-Furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J.Pharmacol.Exp.Ther. 309 1124 PMID: 14976230

Alshurafa et al (2004) A protease activated receptor-2 (PAR-2) activating peptide, tc-LIGRLO-NH₂, induces protease release from mast cells: role in TNF degradation. BMC Pharmacol. 4 12 PMID: 15265236

Olianas et al (2007) Proteinase-activated receptors 1 and 2 in rat olfactory system: layer-specific regulation of multiple signaling pathways in the main olfactory bulb and induction of neurite retraction in olfactory sensory neurons. Neuroscience 146 1289 PMID: 17434682

If you know of a relevant reference for 2-Furoyl-LIGRLO-amide, please let us know.

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关键词: 2-Furoyl-LIGRLO-amide, 2-Furoyl-LIGRLO-amide supplier, Potent, selective, PAR2, agonists, Receptors, Protease-Activated, proteinase-activated, 3015, Tocris Bioscience

3 篇 2-Furoyl-LIGRLO-amide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 2-Furoyl-LIGRLO-amide 的部分引用包括：

Oe et al (2019) Protease-activated receptor 2 protects against VEGF inhibitor-induced glomerular endothelial and podocyte injury. Sci.Rep. 9 2986 PMID: 30814628

Pal et al (2013) Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini. J Biol Chem 288 3265 PMID: 23235155

Sales et al (2015) Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis. Am J Physiol Cell Physiol 34 346 PMID: 24469043

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