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Submit Review2-Iodomelatonin
说明： High affinity melatonin agonist
化学名： N-[2-(2-Iodo-5-methoxyindol-3-yl)ethyl]acetamide
纯度： ≥98% (HPLC)
生物活性 for 2-Iodomelatonin
2-Iodomelatonin is a potent melatonin agonist (pKi values are 10.55 and 9.87 at human recombinant MT1 and MT2 receptors respectively). 2-[125I]-iodomelatonin has been used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.
技术数据 for 2-Iodomelatonin
| 分子量 | 358.18 |
| 公式 | C13H15IN2O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 93515-00-5 |
| PubChem ID | 115348 |
| InChI Key | FJDDSMSDZHURBJ-UHFFFAOYSA-N |
| Smiles | COC1=CC=C2NC(I)=C(CCNC(C)=O)C2=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for 2-Iodomelatonin
参考文献 for 2-Iodomelatonin
参考文献是支持产品生物活性的出版物。
Browning et al (2000) Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors. Br.J.Pharmacol. 129 877 PMID: 10696085
Dubocovich and Takahashi (1987) Use of 2-[125l]-iodomelatonin to characterize melatonin sites in chicken retina. Proc.Natl.Acad.Sci.U.S.A. 84 3916 PMID: 3035559
Suiciak et al (1991) Quantitative pharmacological analysis of 2-[125l]-iodomelatonin binding sites in discrete areas of the chicken brain. J.Neurosci. 11 2855 PMID: 1652626
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关键词: 2-Iodomelatonin, 2-Iodomelatonin supplier, High, affinity, melatonin, agonists, MT, Receptors, Melatonin, (MT), 0737, Tocris Bioscience
5 篇 2-Iodomelatonin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 2-Iodomelatonin 的部分引用包括：
Stauch et al (2019) Structural basis of ligand recognition at the human MT1 melatonin receptor Nature 569 284 PMID: 31019306
Nosjean et al (2000) Identification of the melatonin-binding site MT3 as the quinone reductase 2. J Biol Chem 275 31311 PMID: 10913150
Akoume et al (2019) A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep 9 10074 PMID: 31296888
Hou et al (2017) Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats. Front Cell Neurosci 11 98 PMID: 28473754
Calamini et al (2008) Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2. Biochem J 413 81 PMID: 18254726
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