主页 / 药理学 / GPCRs / 7-TM Receptors / Melatonin Receptors / Melatonin Receptor Agonists / 2-Iodomelatonin

2-Iodomelatonin

Cat. No. 0737 5 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： High affinity melatonin agonist
化学名： N-[2-(2-Iodo-5-methoxyindol-3-yl)ethyl]acetamide
纯度： ≥98% (HPLC)
说明书
引用文献 (5)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 2-Iodomelatonin

2-Iodomelatonin is a potent melatonin agonist (pKi values are 10.55 and 9.87 at human recombinant MT1 and MT2 receptors respectively). 2-[125I]-iodomelatonin has been used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.

技术数据 for 2-Iodomelatonin

分子量 358.18
公式 C13H15IN2O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 93515-00-5
PubChem ID 115348
InChI Key FJDDSMSDZHURBJ-UHFFFAOYSA-N
Smiles COC1=CC=C2NC(I)=C(CCNC(C)=O)C2=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 2-Iodomelatonin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 35.82 100
ethanol 35.82 100

制备储备液 for 2-Iodomelatonin

以下数据基于产品分子量 358.18。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.79 mL 13.96 mL 27.92 mL
5 mM 0.56 mL 2.79 mL 5.58 mL
10 mM 0.28 mL 1.4 mL 2.79 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for 2-Iodomelatonin

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for 2-Iodomelatonin

参考文献是支持产品生物活性的出版物。

Browning et al (2000) Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors. Br.J.Pharmacol. 129 877 PMID: 10696085

Dubocovich and Takahashi (1987) Use of 2-[125l]-iodomelatonin to characterize melatonin sites in chicken retina. Proc.Natl.Acad.Sci.U.S.A. 84 3916 PMID: 3035559

Suiciak et al (1991) Quantitative pharmacological analysis of 2-[125l]-iodomelatonin binding sites in discrete areas of the chicken brain. J.Neurosci. 11 2855 PMID: 1652626

If you know of a relevant reference for 2-Iodomelatonin, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Melatonin Receptor Agonists

关键词: 2-Iodomelatonin, 2-Iodomelatonin supplier, High, affinity, melatonin, agonists, MT, Receptors, Melatonin, (MT), 0737, Tocris Bioscience

5 篇 2-Iodomelatonin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 2-Iodomelatonin 的部分引用包括：

Calamini et al (2008) Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2. Biochem J 413 81 PMID: 18254726

Nosjean et al (2000) Identification of the melatonin-binding site MT3 as the quinone reductase 2. J Biol Chem 275 31311 PMID: 10913150

Stauch et al (2019) Structural basis of ligand recognition at the human MT1 melatonin receptor Nature 569 284 PMID: 31019306

Akoume et al (2019) A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep 9 10074 PMID: 31296888

您是否知道使用了 Tocris 2-Iodomelatonin 的优秀论文？ 请告知我们.

2-Iodomelatonin 的评论

目前没有该产品的评论。 Be the first to review 2-Iodomelatonin and earn rewards!

Have you used 2-Iodomelatonin?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review