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Submit Review2-Palmitoylglycerol is a endogenous fatty acid glycerol ester that enhances activity of 2-arachidonylglycerol (Cat. No. 1298). Does not bind to CB1 or CB2 cannabinoid receptors, but potentiates the apparent binding of 2-AG and increases its ability to inhibit adenylyl cyclase. Enhances in vivo cannabinoid effects of 2-AG following combined administration with 2-linoleoylglycerol.
分子量 | 330.51 |
公式 | C19H38O4 |
储存 | Store at -20°C |
CAS Number | 23470-00-0 |
PubChem ID | 123409 |
InChI Key | BBNYCLAREVXOSG-UHFFFAOYSA-N |
Smiles | OCC(CO)OC(CCCCCCCCCCCCCCC)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Ben-Shabat et al (1998) An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonyl-glycerol cannabinoid activity. Eur.J.Pharmacol. 353 23 PMID: 9721036
Gallily et al (2000) 2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-α production in murine macrophages, and in mice. Eur.J.Pharmacol. 406 R5 PMID: 11011050
Walker et al (2002) Endocannabinoids and related fatty acid derivatives in pain modulation. Chem.Phys.Lipids 121 159 PMID: 12505698
关键词: 2-Palmitoylglycerol, 2-Palmitoylglycerol supplier, Endogenous, lipid, enhances, activity, 2-AG, cannabinoid, receptors, fatty, acid, glycerol, ester, 2-arachidonylglycerol, 2-Palm-Gl, 2-PG, Other, Cannabinoids, 2206, Tocris Bioscience
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