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Submit ReviewHypothalamic RFamide-related neuropeptide. Acts as a natural ligand of the orphan receptor GPR103. Exhibits orexigenic acitivity in mice upon central administration.
分子量 | 2818.18 |
公式 | C127H197N37O36 |
序列 |
VGTALGSLAEELNGYNRKKGGFSFRF (Modifications: Phe-26 = C-terminal amide) |
储存 | Store at -20°C |
CAS Number | 881640-56-8 |
PubChem ID | 90488938 |
InChI Key | QPWYMHBRJDWMIS-AULSSRMGSA-N |
Smiles | [H]N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Kampe et al (2006) Effect of central administration of QRFP(26) peptide on energy balance and characterization of a second QRFP receptor in rat. Brain Res. 1119 133 PMID: 16996040
Le Marec et al (2011) Structure-activity relationships of a series of analogues of the RFamide-related peptide 26RFa J.Med.Chem. 54 4806 PMID: 21623631
Chartrel et al (2003) Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. Proc.Natl.Acad.Sci.USA 100 15247 PMID: 14657341
关键词: 26RFa, 26RFa supplier, rfrp, GPR103, ligands, neuropeptides, orexigenic, appetite, stimulating, stimulators, qrfpr, P518, QRFP, Orphan, 7-TM, Receptors, Other, Peptide, 4402, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 26RFa 的部分引用包括:
Nøhr et al (2017) The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. Neurochem Int 102 105 PMID: 27916541
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