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3-AP

Cat. No. 5962 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5962 has been discontinued.

View all Ribonucleotide Reductase products.
说明： Ribonucleotide reductase inhibitor; also an iron chelator
别名： 3-aminopyridine-2-carboxaldehyde thiosemicarbazone
化学名： 2-[(3-Amino-2-pyridinyl)methylene]hydrazinecarbothioamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for 3-AP

3-AP is a ribonucleotide reductase inhibitor. Also an iron chelator. Inhibits leukemia cell growth and acts in synergy with cisplatin (Cat. No.2251). Active in vivo.

技术数据 for 3-AP

分子量 195.24
公式 C7H9N5S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 143621-35-6
PubChem ID 9571836
InChI Key XMYKNCNAZKMVQN-NYYWCZLTSA-N
Smiles NC(N/N=C/C1=C(C=CC=N1)N)=S

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for 3-AP

参考文献是支持产品生物活性的出版物。

Arid et al (2015) Nucleotide metabolism, oncogene-induced senescence and cancer. Cancer Letters 356 204 PMID: 24486217

Finch et al (1999) Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity. Adv.Enzyme Regul. 39 3 PMID: 10470363

Liu et al (1992) Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone. J.Med.Chem. 35 3672 PMID: 1433178

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关键词: 3-AP, 3-AP supplier, Ribonucleotide, reductase, inhibitors, inhibits, chelator, leukemia, cisplatin, active, in, vivo, 3-aminopyridine-2-carboxaldehyde, thiosemicarbazone, Reductase, DNA,, RNA, and, Protein, Synthesis, Biochemicals, Molecular, Biology, 5962, Tocris Bioscience

1 篇 3-AP 的引用文献

引用文献是使用了 Tocris 产品的出版物。 3-AP 的部分引用包括：

Chitambar et al (2013) Iron-targeting antitumor activity of gal. compounds and novel insights into triapine(®)-metal complexes. Antioxid.Redox Signal. 18 956 PMID: 22900955

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