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Submit Review3-Bromocytisine
说明： Potent α4β4, α4β2 and α7 nAChR agonist
化学名： (1R,5S)-9-Bromo-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
纯度： ≥98% (HPLC)
生物活性 for 3-Bromocytisine
3-Bromocytisine is a potent agonist of α4β4, α4β2 and α7 nACh receptors (IC50 values are 0.28, 0.30 and 31.6 nM respectively). Displays different effects on high (HS) and low (LS) ACh sensitivity α4β2 nAChRs (EC50 values are 0.008 and 0.05 μM respectively).
技术数据 for 3-Bromocytisine
| 分子量 | 269.14 |
| 公式 | C11H13BrN2O |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 207390-14-5 |
| PubChem ID | 15519735 |
| InChI Key | DWDCLEHDNICBMI-JGVFFNPUSA-N |
| Smiles | O=C2N1C[C@@]([H])(C3)CNC[C@@]([H])3C1=CC=C2Br |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for 3-Bromocytisine
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 26.91 | 100 | |
| DMSO | 26.91 | 100 |
制备储备液 for 3-Bromocytisine
以下数据基于产品分子量 269.14。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.72 mL | 18.58 mL | 37.16 mL |
| 5 mM | 0.74 mL | 3.72 mL | 7.43 mL |
| 10 mM | 0.37 mL | 1.86 mL | 3.72 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
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产品说明书 for 3-Bromocytisine
参考文献 for 3-Bromocytisine
参考文献是支持产品生物活性的出版物。
Houlihan et al (2001) Activity of cytisine and its brominated isoteres on recombinant human α7, α4β2 and α4β4 nicotinic acetylcholine receptors. J.Neurochem. 78 1029 PMID: 11553677
Moroni et al (2006) α4β2 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine. Mol.Pharmacol. 70 755 PMID: 16720757
If you know of a relevant reference for 3-Bromocytisine, please let us know.
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关键词: 3-Bromocytisine, 3-Bromocytisine supplier, 3-Br-Cytisine, nACh, receptor, agonist, nicotinic, acetylcholine, receptors, a4b4, a4b2, a7, agonists, alpha4beta4, alpha4beta2, alpha7, Nicotinic, (a4b2), Receptors, (Other, Subtypes), (a7), (Non-selective), 3549, Tocris Bioscience
1 篇 3-Bromocytisine 的引用文献
引用文献是使用了 Tocris 产品的出版物。 3-Bromocytisine 的部分引用包括：
Kiss et al (2014) Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. PLoS One 9 e109538 PMID: 25303328
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.