Nicotinic (α7) Receptors
Alpha 7 (α7) is a subunit of the neuronal nicotinic receptor that can combine to form homomeric receptors. The α7 nAChR is prominent in the hippocampus, found on GABAergic interneurons of stratum oriens and stratum radiatum, and on pyramidal neurones.
Nicotinic (α7) Receptor Agonists |
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|---|---|
| Cat. No. | Product Name / Activity |
| 4341 | A 582941 |
| α7 nAChR partial agonist | |
| 3549 | 3-Bromocytisine |
| Potent α4β4, α4β2 and α7 nAChR agonist | |
| 3092 | PHA 543613 hydrochloride |
| Potent and selective α7 nAChR agonist | |
| 3134 | PHA 568487 |
| Selective α7 nAChR agonist | |
| 2303 | PNU 282987 |
| Selective α7 nAChR agonist | |
| 3518 | S 24795 |
| α7 nAChR partial agonist | |
| 5559 | SSR 180711 hydrochloride |
| Selective α7 nAChR partial agonist | |
Nicotinic (α7) Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 2813 | D-Amphetamine sulfate |
| α7 nAChR antagonist; also induces dopamine, 5-HT and noradrenalin release | |
| 2133 | α-Bungarotoxin |
| Selective α7 nAChR antagonist | |
| 3405 | COG 133 |
| α7 nAChR antagonist; ApoE peptide fragment | |
| 1029 | Methyllycaconitine citrate |
| Selective α7 neuronal nAChR antagonist | |
| 2459 | Tropisetron hydrochloride |
| α7 nAChR partial agonist; also potent 5-HT3 antagonist | |
Nicotinic (α7) Receptor Modulators |
|
| Cat. No. | Product Name / Activity |
| 4571 | A 867744 |
| Positive allosteric modulator of α7 nAChRs | |
| 6764 | B 973B |
| Positive allosteric modulator of α7 nAChRs; analgesic | |
| 3837 | CCMI |
| Positive allosteric modulator of α7 nAChRs | |
| 1260 | Ivermectin |
| Positive allosteric modulator of α7 nAChRs; also positive allosteric modulator of P2X4 receptors | |
| 4141 | LY 2087101 |
| Allosteric potentiator of α7, α4β2 and α4β4 nAChRs | |
| 2995 | NS 1738 |
| Positive allosteric modulator of α7 nAChRs; active in vivo | |
| 2498 | PNU 120596 |
| Positive allosteric modulator of α7 nAChRs; active in vivo | |
α7 is a subunit of the neuronal nicotinic receptor that can combine to form homomeric receptors. In avian tissue α7α8 heteromers also occur and an association between α7 and β2 subunits has been suggested in the mammalian brain. The α7 nAChR is particularly prominent in the hippocampus, where it is found on GABAergic interneurons of stratum oriens and stratum radiatum, and on pyramidal neurones.
Presynaptic α7 nAChRs are present on glutamate terminals and facilitate transmitter release in various brain regions, including the hippocampus, cortex and ventral tegmental area. Nicotine acting at α7 nAChRs can enhance hippocampal LTP, and α7 nAChRs are associated with attentional processes and working memory. As a consequence, α7 nAChRs are a therapeutic target for treating cognitive impairment, notably in Alzheimer's disease and schizophrenia, and this has prompted the generation of α7 nAChR-selective ligands. The human gene encoding the nicotinic α7 receptor subunit has been localized to chromosome 15 (15q13.3).
External sources of pharmacological information for Nicotinic (α7) Receptors :
Literature for Nicotinic (α7) Receptors
Tocris offers the following scientific literature for Nicotinic (α7) Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.
Our Nicotinic Acetylcholine Receptor review summarizes the structure and function of nAChR receptors, and the pharmacological ligands used to study them.
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Our Alzheimer's disease poster summarizes the genetic, molecular and cellular changes observed in the progression of this neurodegenerative disease.
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