4,9-Anhydrotetrodotoxin

Name: 4,9-Anhydrotetrodotoxin
Brand: Tocris Bioscience
SKU: 6159

Cat. No. 6159 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6159 has been discontinued.

View all Voltage-gated Sodium (Na<sub>V</sub>) Channels products.

说明： Potent and selective Na_v1.6 channel blocker

别名： 4,9-anhydro-TTX

化学名： (4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-Amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol

纯度： ≥98% (HPLC)

说明书

引用文献 (4)

生物活性技术数据说明书参考文献

生物活性 for 4,9-Anhydrotetrodotoxin

4,9-Anhydrotetrodotoxin is a potent and selective Na_v1.6 channel blocker (IC₅₀ values are 7.8, 341, 988, 1260, 1270, 78500 and >30000 nM for Na_v1.6, Na_v1.3, Na_v1.4, Na_v1.2, Na_v1.7, Na_v1.5 and Na_v1.8). Derivative of tetrodotoxin (Cat. No. 1078).

技术数据 for 4,9-Anhydrotetrodotoxin

分子量	301.25
公式	C₁₁H₁₅N₃O₇
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	13072-89-4
PubChem ID	11243537
InChI Key	STNXQECXKDMLJK-PZKHIREQSA-N
Smiles	O[C@@]1(CO)[C@H](O2)[C@H]([C@H](O3)NC(N4[H])=N)[C@]54[C@H]3[C@@]2(O)O[C@H]1[C@H]5O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for 4,9-Anhydrotetrodotoxin

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 4,9-Anhydrotetrodotoxin

参考文献是支持产品生物活性的出版物。

Rosker et al (2007) The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Na_v1.6 voltage-dependent sodium channel. Am.J.Physiol.Cell Physiol. 293 C783 PMID: 17522141

Hargus et al (2013) Evidence for a role of Na_v1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis J.Neurophysiol 110 1144 PMID: 23741036

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