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说明： Inhibits IRE1α endoribonuclease activity
化学名： 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde
纯度： ≥98%
生物活性 for 4μ8C
4μ8C is a selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Blocks substrate access to the active site of IRE1α. Inactivates IRE1α-mediated mRNA degradation. Displays no effect on the IRE1α-related endoribonuclease RNase L.
化合物库 for 4μ8C
4mu8C is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for 4μ8C
| 分子量 | 204.18 |
| 公式 | C11H8O4 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% |
| CAS Number | 14003-96-4 |
| PubChem ID | 12934390 |
| InChI Key | RTHHSXOVIJWFQP-UHFFFAOYSA-N |
| Smiles | CC(C1=CC=C(O)C(C=O)=C1O2)=CC2=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for 4μ8C
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 20.42 | 100 |
制备储备液 for 4μ8C
以下数据基于产品分子量 204.18。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.9 mL | 24.49 mL | 48.98 mL |
| 5 mM | 0.98 mL | 4.9 mL | 9.8 mL |
| 10 mM | 0.49 mL | 2.45 mL | 4.9 mL |
| 50 mM | 0.1 mL | 0.49 mL | 0.98 mL |
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产品说明书 for 4μ8C
参考文献 for 4μ8C
参考文献是支持产品生物活性的出版物。
Cross et al (2012) The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc.Natl.Acad.Sci.USA 109 E869 PMID: 22315414
If you know of a relevant reference for 4μ8C, please let us know.
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关键词: 4mu8C, 4mu8C supplier, 4m8C, 4mu8C, 4μ8C, selective, inhibitors, inhibits, ire1, rnase, endoribonuclease, 4u8c, IRE1, 4479, Tocris Bioscience
10 篇 4μ8C 的引用文献
引用文献是使用了 Tocris 产品的出版物。 4μ8C 的部分引用包括：
Lisa G M et al (2022) Saponin-based adjuvant-induced dendritic cell cross-presentation is dependent on PERK activation. Cell Mol Life Sci 79 231 PMID: 35396971
Li-ying et al (2022) CDNF Interacts with ER Chaperones and Requires UPR Sensors to Promote Neuronal Survival. Int J Mol Sci 23 PMID: 36012764
Judith A et al (2019) Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis. Sci Transl Med 11 PMID: 30728287
Benoit et al (2019) Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR. Cell 177 1201-1216.e19 PMID: 31031005
Mihee M et al (2019) Evaluation of Compound Activity in Primary Human Intestinal Organoids Using Gene Expression and Histology. Curr Protoc Pharmacol 85 e54 PMID: 30920154
Yahui et al (2019) Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR. Elife 8 PMID: 31873072
Yuren et al (2020) Monounsaturated fatty acids protect against palmitate-induced lipoapoptosis in human umbilical vein endothelial cells. PLoS One 14 e0226940 PMID: 31891641
Amin-Wetzel et al (2017) A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response. Cell 171 1625 PMID: 29198525
Mart et al (2021) The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor. J Biol Chem 296 100295 PMID: 33460650
Beisel (2017) TLR7-mediated activation of XBP1 correlates with the IFNα production in humans Cytokine 94 55 PMID: 28408069
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets