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5,7-Dichlorokynurenic acid sodium salt

Cat. No. 3698 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent NMDA antagonist, acts at glycine site; sodium salt of 5,7-Dichlorokynurenic acid
化学名： 5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid sodium salt
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
文献 (5)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 5,7-Dichlorokynurenic acid sodium salt

5,7-Dichlorokynurenic acid sodium salt is a sodium salt of 5,7-Dichlorokynurenic acid (Cat. No. 0286), a potent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine).

技术数据 for 5,7-Dichlorokynurenic acid sodium salt

分子量 280.04
公式 C10H4Cl2NNaO3
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 1184986-70-6
PubChem ID 44134672
InChI Key VPRPMJHKWHCUFW-UHFFFAOYSA-M
Smiles [Na+].OC1=CC(=NC2=CC(Cl)=CC(Cl)=C12)C([O-])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 5,7-Dichlorokynurenic acid sodium salt

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
1eq. NaOH 28 100

制备储备液 for 5,7-Dichlorokynurenic acid sodium salt

以下数据基于产品分子量 280.04。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.57 mL 17.85 mL 35.71 mL
5 mM 0.71 mL 3.57 mL 7.14 mL
10 mM 0.36 mL 1.79 mL 3.57 mL
50 mM 0.07 mL 0.36 mL 0.71 mL

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产品说明书 for 5,7-Dichlorokynurenic acid sodium salt

分析证书/产品说明书
化学品安全技术说明书

参考文献 for 5,7-Dichlorokynurenic acid sodium salt

参考文献是支持产品生物活性的出版物。

Baron et al (1990) Activity of 5,7-dichlorokynurenic acid. A potent antagonist at the NMDA receptor-associated glycine binding site. Mol.Pharmacol. 38 554 PMID: 2172769

Moore et al (1990) Substituted kynurenic acid derivatives. Potent and selective antagonists at the glycine site on the NMDA receptor. Eur.Fed.Med.Chem. (under auspices of IUPAC) XIth I

If you know of a relevant reference for 5,7-Dichlorokynurenic acid sodium salt, please let us know.

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关键词: 5,7-Dichlorokynurenic acid sodium salt, 5,7-Dichlorokynurenic acid sodium salt supplier, Potent, NMDA, antagonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, 3698, Tocris Bioscience

2 篇 5,7-Dichlorokynurenic acid sodium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 5,7-Dichlorokynurenic acid sodium salt 的部分引用包括：

Rafael et al (2022) GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits. Neuron 110 2438-2454.e8 PMID: 35700736

Lan-Zhen et al (2019) Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition. Cell Chem Biol 26 121-130.e5 PMID: 30472117

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