5'-Fluoroindirubinoxime

Name: 5'-Fluoroindirubinoxime
Brand: Tocris Bioscience
SKU: 4033

Cat. No. 4033 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4033 has been discontinued.

View all FLT3 products.

说明： FLT3 inhibitor; displays antiproliferative activity

化学名： 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione 3-oxime

纯度： ≥99% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for 5'-Fluoroindirubinoxime

5'-Fluoroindirubinoxime is an inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) (IC₅₀ = 15 nM). Displays selectivity for FLT3 against 6 other kinases including EGFR. Displays antiproliferative activity against the MV4;11 cell line (expressing constitutively active FLT3) and a number of cancer cell lines, including SNU-638 (stomach carcinoma) and HT-1080 (fibrosarcoma).

许可信息

Sold under licence from Anygen Co. Ltd.

技术数据 for 5'-Fluoroindirubinoxime

分子量	295.27
公式	C₁₆H₁₀FN₃O₂
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	861214-33-7
PubChem ID	11580208
InChI Key	LBUXOYSDWHGJNP-UHFFFAOYSA-N
Smiles	O=C(NC4=C3C=C(F)C=C4)/C3=C2NC1=CC=CC=C1C/2=NO

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for 5'-Fluoroindirubinoxime

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 5'-Fluoroindirubinoxime

参考文献是支持产品生物活性的出版物。

Kim et al (2007) Antitumor activity of novel indirubin derivatives in rat tumor model. Clin.Cancer Res. 13 253 PMID: 17200363

Krivogorsky et al (2008) Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs. Antimicrob.Agents Chemother. 52 4466 PMID: 18824607

Choi et al (2010) Indiribuin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells. Bioorg.Med.Chem.Lett. 20 2033 PMID: 20153646

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关键词: 5'-Fluoroindirubinoxime, 5'-Fluoroindirubinoxime supplier, FMS-like, receptor, tyrosine, kinase-3, FLT3, inhibitors, inhibits, antiproliferative, 5-Fluoroindirubinoxime, 4033, Tocris Bioscience

篇 5'-Fluoroindirubinoxime 的引用文献

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