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Submit Review5'-Iodoresiniferatoxin
说明： Potent, silent TRPV1 antagonist
别名： Iodoresiniferatoxin,5'-IRTX
化学名： 6,7-Deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(phenylmethyl)-daphnetoxin,20-(4-hydroxy-5-iodo-3-methoxybenzeneacetate)
纯度： ≥98% (HPLC)
生物活性 for 5'-Iodoresiniferatoxin
Potent and silent vanilloid receptor antagonist, 40-fold more potent than capsazepine (Cat. No. 0464). Binds to TRPV1 (VR1) receptors expressed in HEK293 cells with a Ki of 5.8 nM.
技术数据 for 5'-Iodoresiniferatoxin
| 分子量 | 754.6 |
| 公式 | C37H39IO9 |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 535974-91-5 |
| PubChem ID | 16219535 |
| InChI Key | TZUJORCXGLGWDV-RYACRXIZSA-N |
| Smiles | O=C1C(C)=C[C@]2([H])[C@@](O)1CC(COC(CC5=CC(I)=C(O)C(OC)=C5)=O)=C[C@]3([H])[C@@](O6)2[C@H](C)C[C@@]4(C(C)=C)[C@@H]3OC6(CC7=CC=CC=C7)O4 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for 5'-Iodoresiniferatoxin
参考文献 for 5'-Iodoresiniferatoxin
参考文献是支持产品生物活性的出版物。
Marinelli et al (2002) Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus in vitro. J.Physiol. 543 531 PMID: 12205187
Wahl et al (2001) Iodo-resiniferatoxin, a new potent vanilloid receptor antagonist. Mol.Pharmacol. 59 9 PMID: 11125018
Seabrook et al (2001) Properties of iodo-resiniferatoxin - a high affinity VR1 vanilloid receptor antagonist. Soc.Neurosci.Abstr. 925.9
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关键词: 5'-Iodoresiniferatoxin, 5'-Iodoresiniferatoxin supplier, Potent, silent, TRPV1, antagonists, Vanillioid, Receptors, VR1, Channels, Transient, Receptor, Potential, 5-Iodoresiniferatoxin, 5-IRTX, Iodoresiniferatoxin, 5'-IRTX, TRPV, 1362, Tocris Bioscience
16 篇 5'-Iodoresiniferatoxin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 5'-Iodoresiniferatoxin 的部分引用包括：
Barbonetti et al (2010) Energetic metabolism and human sperm motility: impact of CB1 receptor activation. Endocrinology 151 5882 PMID: 20962050
Woolcott et al (2015) High-fat diet-induced Ins resistance does not increase plasma anandamide levels or potentiate anandamide Insotropic effect in isolated canine islets. J Neurosci Res 10 e0123558 PMID: 25855974
Vigna (2014) 5-Aminosalicylic Acid Inhibits Acute Clostridium difficile Toxin A-Induced Colitis in Rats. PLoS One 2014 389621 PMID: 25045574
Capasso et al (2014) Palmitoylethanolamide normalizes intestinal motility in a model of post-inflammatory accelerated transit: involvement of CB? receptors and TRPV1 channels. Br J Pharmacol 171 4026 PMID: 24818658
Raboune et al (2014) Novel endogenous N-acyl amides activate TRPV1-4 receptors, BV-2 microglia, and are regulated in brain in an acute model of inflammation. Front Cell Neurosci 8 195 PMID: 25136293
Gao et al (2012) Transient receptor potential vanilloid type 1-dependent regulation of liver-related neurons in the paraventricular nucleus of the hypothalamus diminished in the type 1 diabetic mouse. Pain 61 1381 PMID: 22492526
Ruparel et al (2012) Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. J Neurosci 153 2031 PMID: 22633978
Kim et al (2018) Analgesic effects of FAAH inhibitor in the insular cortex of nerve-injured rats. Mol Pain 14 1744806918814340 PMID: 30380982
Zsombok et al (2011) Functional plasticity of central TRPV1 receptors in brainstem dorsal vagal complex circuits of streptozotocin-treated hyperglycemic mice. PLoS One 31 14024 PMID: 21957263
Musella (2017) A novel crosstalk within the endocannabinoid system controls GABA transmission in the striatum. Sci Rep 7 7363 PMID: 28779174
Xu et al (2009) Increases in transient receptor potential vanilloid-1 mRNA and protein in primary afferent neurons stimulated by protein kinase C and their possible role in neurogenic inflammation. Int J Inflam 87 482 PMID: 18752301
El-Hashim and Jaffal (2009) Nerve growth factor enhances cough and airway obstruction via TrkA receptor- and TRPV1-dependent mechanisms. Thorax 64 791 PMID: 19497920
Price et al (2004) Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons. Br J Pharmacol 142 257 PMID: 15155534
Gavva et al (2005) AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J Pharmacol Exp Ther 313 474 PMID: 15615864
Derbenev et al (2006) Vanilloid-mediated heterosynaptic facilitation of inhibitory synaptic input to neurons of the rat dorsal motor nucleus of the vagus. J Neurosci 26 9666 PMID: 16988037
Marinelli et al (2007) N-arachidonoyl-DA tunes synaptic transmission onto DArgic neurons by activating both cannabinoid and vanilloid receptors. Neuropsychopharmacology 32 298 PMID: 16760924
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