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Submit Review7,8-Dihydroxyflavone
说明： TrkB agonist
别名： 7,8-DHF
化学名： 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one
纯度： ≥98% (HPLC)
生物活性 for 7,8-Dihydroxyflavone
7,8-Dihydroxyflavone is a tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (Kd = 320 nM). Inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo. Exhibits neuroprotective effects in an HD mouse model.
技术数据 for 7,8-Dihydroxyflavone
| 分子量 | 254.24 |
| 公式 | C15H10O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 38183-03-8 |
| PubChem ID | 1880 |
| InChI Key | COCYGNDCWFKTMF-UHFFFAOYSA-N |
| Smiles | O=C2C1=CC=C(O)C(O)=C1OC(C3=CC=CC=C3)=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for 7,8-Dihydroxyflavone
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 25.42 | 100 | |
| 2eq. NaOH | 25.42 | 100 |
制备储备液 for 7,8-Dihydroxyflavone
以下数据基于产品分子量 254.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.93 mL | 19.67 mL | 39.33 mL |
| 5 mM | 0.79 mL | 3.93 mL | 7.87 mL |
| 10 mM | 0.39 mL | 1.97 mL | 3.93 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.79 mL |
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产品说明书 for 7,8-Dihydroxyflavone
参考文献 for 7,8-Dihydroxyflavone
参考文献是支持产品生物活性的出版物。
Jang et al (2010) A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc.Natl.Acad.Sci.USA 107 268
Andero et al (2012) 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilzation stress in rats. Hippocampus 22 399 PMID: 21136519
Jiang et al (2013) Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease. Hum.Mol.Genet. 22 2462 PMID: 23446639
If you know of a relevant reference for 7,8-Dihydroxyflavone, please let us know.
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关键词: 7,8-Dihydroxyflavone, 7,8-Dihydroxyflavone supplier, agonists, TrkB, Neurotrophin, Receptors, Tyrosine, Kinases, RTKs, 7,8-DHF, Trk, 3826, Tocris Bioscience
10 篇 7,8-Dihydroxyflavone 的引用文献
引用文献是使用了 Tocris 产品的出版物。 7,8-Dihydroxyflavone 的部分引用包括：
Shamblott et al (2016) Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2 (TRKB) signaling in the adult human exocrine pancreas. Cell Communication and Signaling 14 23 PMID: 27659207
Chen et al (2014) BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals. Eur J Neurosci 39 1439 PMID: 24611998
Abcejo et al (2012) Brain-derived neurotrophic factor enhances calcium regulatory mechanisms in human airway smooth muscle. Int J Mol Sci 7 e44343 PMID: 22952960
Greising et al (2017) Chronic TrkB agonist treatment in old age does not mitigate diaphragm neuromuscular dysfunction. Physiol Rep 5 PMID: 28082429
Chitranshi et al (2015) Exploring the Molecular Interactions of 7,8-Dihydroxyflavone and Its Derivatives with TrkB and VEGFR2 Proteins. Purinergic Signal 16 21087 PMID: 26404256
Kee K et al (2022) Bisphenol-A impairs synaptic formation and function by RGS4-mediated regulation of BDNF signaling in the cerebral cortex. Dis Model Mech 15 PMID: 35781563
Choi et al (2013) Effect of 7,8-dihydroxyflavone as an antioxidant on in vitro maturation of oocytes and development of parthenogenetic embryos in pigs. Muscle Nerve 59 450 PMID: 23748647
Meltser et al (2014) TrkB-mediated protection against circadian sensitivity to noise trauma in the murine cochlea. Curr Biol 24 658 PMID: 24583017
Al-Qudah et al (2014) Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C. Am J Physiol Gastrointest Liver Physiol 306 G328 PMID: 24356881
Mantilla and Ermilov (2012) The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission. PLoS One 45 274 PMID: 22246885
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
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Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.