7,8-Dihydroxyflavone

Pricing Availability   Qty
说明: TrkB agonist
别名: 7,8-DHF
化学名: 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one
纯度: ≥98% (HPLC)
说明书
引用文献 (10)
评论
文献 (3)

生物活性 for 7,8-Dihydroxyflavone

7,8-Dihydroxyflavone is a tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (Kd = 320 nM). Inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo. Exhibits neuroprotective effects in an HD mouse model.

技术数据 for 7,8-Dihydroxyflavone

分子量 254.24
公式 C15H10O4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 38183-03-8
PubChem ID 1880
InChI Key COCYGNDCWFKTMF-UHFFFAOYSA-N
Smiles O=C2C1=CC=C(O)C(O)=C1OC(C3=CC=CC=C3)=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 7,8-Dihydroxyflavone

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 25.42 100
2eq. NaOH 25.42 100

制备储备液 for 7,8-Dihydroxyflavone

以下数据基于产品分子量 254.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.93 mL 19.67 mL 39.33 mL
5 mM 0.79 mL 3.93 mL 7.87 mL
10 mM 0.39 mL 1.97 mL 3.93 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

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产品说明书 for 7,8-Dihydroxyflavone

分析证书/产品说明书
选择另一批次:

参考文献 for 7,8-Dihydroxyflavone

参考文献是支持产品生物活性的出版物。

Jang et al (2010) A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc.Natl.Acad.Sci.USA 107 268

Andero et al (2012) 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilzation stress in rats. Hippocampus 22 399 PMID: 21136519

Jiang et al (2013) Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease. Hum.Mol.Genet. 22 2462 PMID: 23446639


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查看全部 Trk Receptor Agonists

关键词: 7,8-Dihydroxyflavone, 7,8-Dihydroxyflavone supplier, agonists, TrkB, Neurotrophin, Receptors, Tyrosine, Kinases, RTKs, 7,8-DHF, Trk, 3826, Tocris Bioscience

10 篇 7,8-Dihydroxyflavone 的引用文献

引用文献是使用了 Tocris 产品的出版物。 7,8-Dihydroxyflavone 的部分引用包括:

Chen et al (2014) BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals. Eur J Neurosci 39 1439 PMID: 24611998

Kee K et al (2022) Bisphenol-A impairs synaptic formation and function by RGS4-mediated regulation of BDNF signaling in the cerebral cortex. Dis Model Mech 15 PMID: 35781563

Shamblott et al (2016) Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2 (TRKB) signaling in the adult human exocrine pancreas. Cell Communication and Signaling 14 23 PMID: 27659207

Abcejo et al (2012) Brain-derived neurotrophic factor enhances calcium regulatory mechanisms in human airway smooth muscle. Int J Mol Sci 7 e44343 PMID: 22952960


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