7α,25-Dihydroxycholesterol

Name: 7α,25-Dihydroxycholesterol
Brand: Tocris Bioscience
SKU: 6277

Cat. No. 6277 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6277 has been discontinued.

View all Orphan 7-TM Receptors products.

说明： Highly potent GPR183 (EBI2) agonist

化学名： (3β,7α)-Cholest-5-ene-3,7,25-triol

纯度： ≥98% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for 7α,25-Dihydroxycholesterol

7α,25-Dihydroxycholesterol is a highly potent GPR183 (EBI2) agonist (EC₅₀ = 140 pM) and putative natural ligand for GPR183. Regulates migration of B and T cells expressing GPR183 in vivo. Desensitizes B cells and reduces their movement to splenic follicles.

技术数据 for 7α,25-Dihydroxycholesterol

分子量	418.65
公式	C₂₇H₄₆O₃
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	64907-22-8
PubChem ID	11954197
InChI Key	BQMSKLCEWBSPPY-IKVTXIKFSA-N
Smiles	O[C@H](C1)CC[C@@]2(C)C1=C[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCCC(C)(O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for 7α,25-Dihydroxycholesterol

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 7α,25-Dihydroxycholesterol

参考文献是支持产品生物活性的出版物。

Liu et al (2011) Oxysterols direct B-cell migration through EBI2. Nature. 475 519 PMID: 21796211

Hannedouche et al (2011) Oxysterols direct immune cell migration via EBI2. Nature. 475 524 PMID: 21796212

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篇 7α,25-Dihydroxycholesterol 的引用文献

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