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7rh

Cat. No. 5860 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective DDR1 inhibitor; orally bioavailable
化学名： 4-Ethyl-N-[3-[(4-methyl-1-piperazinyl)methyl]-5-(trifluoromethyl)phenyl]-3-(2-pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzamide
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for 7rh

7rh is a potent and selective DDR1 inhibitor (IC50 = 6.8 nM). Exhibits selectivity for DDR1 over DDR2, Bcr-Abl and c-Kit (IC50 values are 101.4 and 355 nM and > 10 μM, respectively) and a range of other kinases. Inhibits proliferation of cancer cell lines expressing high levels of DDR1 in vitro and suppresses cancer cell invasion, adhesion and tumorigenicity. Orally bioavailable.

技术数据 for 7rh

分子量 546.59
公式 C30H29F3N6O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1429617-90-2
PubChem ID 71550931
InChI Key DDLPXZXBWGJRGK-UHFFFAOYSA-N
Smiles O=C(NC1=CC(CN2CCN(C)CC2)=CC(C(F)(F)F)=C1)C3=CC(C#CC(C=N4)=CN5C4=CC=N5)=C(CC)C=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 7rh

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 54.66 100

制备储备液 for 7rh

以下数据基于产品分子量 546.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.83 mL 9.15 mL 18.3 mL
5 mM 0.37 mL 1.83 mL 3.66 mL
10 mM 0.18 mL 0.91 mL 1.83 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

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产品说明书 for 7rh

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for 7rh

参考文献是支持产品生物活性的出版物。

Gao et al (2013) Discovery and optimization of 3-(2-(pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors. J.Med.Chem. 56 3281 PMID: 23521020

If you know of a relevant reference for 7rh, please let us know.

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关键词: 7rh, 7rh supplier, Discoidin, domain, receptors, 1, inhibitors, inhibits, potent, selective, DDR1, orally, bioavailable, Other, RTKs, 5860, Tocris Bioscience

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