8-Bromo-cGMP, sodium salt

Cat. No. 1089 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： cGMP analog; activates PKG

化学名： 8-Bromoguanosine cyclic 3',5'-monophosphate sodium salt

纯度： ≥98% (HPLC)

引用文献 (3)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 8-Bromo-cGMP, sodium salt

8-Bromo-cGMP, sodium salt is a membrane permeable cGMP analog that activates protein kinase G (PKG). 4.3-fold more potent than cGMP in activating PKG1α and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro.

技术数据 for 8-Bromo-cGMP, sodium salt

分子量	446.09
公式	C₁₀H₁₀BrN₅NaO₇P
储存	Desiccate at -20°C
纯度	≥98% (HPLC)
CAS Number	51116-01-9
PubChem ID	23702959
InChI Key	ZJRFCXHKYQVNFK-YEOHUATISA-M
Smiles	[Na+].[H][C@@]12COP([O-])(=O)O[C@@]1([H])[C@@H](O)[C@@H](O2)N1C(Br)=NC2=C1NC(N)=NC2=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 8-Bromo-cGMP, sodium salt

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	44.61	100

制备储备液 for 8-Bromo-cGMP, sodium salt

以下数据基于产品分子量 446.09。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.21 mL	22.42 mL
5 mM	0.45 mL	2.24 mL	4.48 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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产品说明书 for 8-Bromo-cGMP, sodium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 8-Bromo-cGMP, sodium salt

参考文献是支持产品生物活性的出版物。

Buchan et al (1991) Modulation of agonist-induced calcium mobilisation in bovine aortic endothelial cells by phorbol myristate acetate and cyclic AMP but not cyclic GMP. Br.J.Pharmacol. 104 361 PMID: 1665733

Ignarro et al (1974) Stimulation of phagocytic release of neutral protease from human neutrophils by cholinergic amines and cyclic 3',5'-guanosine monophosphate. J.Immunol. 112 210 PMID: 4359834

Sekhar et al (1992) Relaxation of pig coronary arteries by new and potent cGMP analogs that selectively activate type 1α, compared with type 1β, cGMP-dependent protein kinase. Mol.Pharmacol. 42 103 PMID: 1321950

If you know of a relevant reference for 8-Bromo-cGMP, sodium salt, please let us know.

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关键词: 8-Bromo-cGMP, sodium salt, 8-Bromo-cGMP, sodium salt supplier, cGMP, analog, activates, PKG, protein, kinase, G, activator, Heterotrimeric, G-protein, GTPases, Protein, Kinase, 1089, Tocris Bioscience

3 篇 8-Bromo-cGMP, sodium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 8-Bromo-cGMP, sodium salt 的部分引用包括：

Capuano et al (2009) Proinflammatory-activated trigeminal satellite cells promote neuronal sensitization: relevance for migraine pathology. Mol Pain 5 43 PMID: 19660121

Huang and Hsu (2010) Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex 20 982 PMID: 19666830

Foster et al (2014) Nitric oxide-mediated modulation of the murine locomotor network. J Neurophysiol 111 659 PMID: 24259545

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