8MDP

Cat. No. 4588 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent equilibrative nucleoside transporter (ENT) inhibitor

化学名： 2,2',2'',2'''-[[4,8-Bis(hexahydro-1(2H)-azocinyl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo]tetrakisethanol

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 8MDP

8MDP is a potent equilibrative nucleoside transporter 1 (ENT1) inhibitor (IC₅₀ = 0.43 nM). Inhibits hENT1 and hENT2 uptake of [H³]uridine in K562 cells and K15NTD cells respectively.

化合物库 for 8MDP

8MDP is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for 8MDP

分子量	560.73
公式	C₂₈H₄₈N₈O₄
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	29491-75-6
PubChem ID	16756415
InChI Key	KXOCTHJHIGLQKJ-UHFFFAOYSA-N
Smiles	OCCN(CCO)C2=NC1=C(N3CCCCCCC3)N=C(N(CCO)CCO)N=C1C(N4CCCCCCC4)=N2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 8MDP

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	11.21	20

制备储备液 for 8MDP

以下数据基于产品分子量 560.73。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	8.92 mL	44.58 mL	89.17 mL
1 mM	1.78 mL	8.92 mL	17.83 mL
2 mM	0.89 mL	4.46 mL	8.92 mL
10 mM	0.18 mL	0.89 mL	1.78 mL

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产品说明书 for 8MDP

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 8MDP

参考文献是支持产品生物活性的出版物。

Lin et al (2011) Design, synthesis, and evaluation of 2-diethanolamino-4,8-diheptamethyleneimino-2-(N-aminoethyl-N-ethanolamino)-6-(N,N-diethanolamino)pyrimido[5,4-d]pyrimidine-fluorescein conjugate (8MDP-fluor), as a novel equilibrativ Bioconjug.Chem. 22 1221 PMID: 21539390

Lin et al (2007) Synthesis, flow cytometric evaluation, and identification of highly potent dipyrid. analogues as equilibrative nucleoside transporter 1 inhibitors. J.Med.Chem. 50 3906 PMID: 17636949

If you know of a relevant reference for 8MDP, please let us know.

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关键词: 8MDP, 8MDP supplier, ENT1, inhibitors, inhibits, potent, equilibrative, nucleoside, transporters, 1, 2, ENT2, transports, Nucleoside, Transporters, 4588, Tocris Bioscience

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