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A 1120

Cat. No. 3793 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： High affinity retinol-binding protein 4 (RBP4) ligand
化学名： 2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for A 1120

A 1120 is a high affinity retinol-binding protein 4 (RBP4) ligand (Ki = 8.3 nM); non-retinoid. Selective against a range of different cellular targets. As efficacious as fenretinide (Cat. No. 1396) in the reduction of serum RBP4 and retinol. Displaces transthyretin (TTR) from RBP4-TTR complexes.

化合物库 for A 1120

A 1120 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for A 1120

分子量 392.37
公式 C20H19F3N2O3
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 1152782-19-8
PubChem ID 25138295
InChI Key MEAQCLPMSVEOQF-UHFFFAOYSA-N
Smiles O=C(NC3=C(C(O)=O)C=CC=C3)N1CCC(C2=C(C(F)(F)F)C=CC=C2)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for A 1120

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 39.24 100
ethanol 9.81 25

制备储备液 for A 1120

以下数据基于产品分子量 392.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.74 mL 25.49 mL
5 mM 0.51 mL 2.55 mL 5.1 mL
10 mM 0.25 mL 1.27 mL 2.55 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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产品说明书 for A 1120

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for A 1120

参考文献是支持产品生物活性的出版物。

Manolescu et al (2009) All-trans retinoic acid lowers serum retinol-binding protein 4 concentrations and increases Ins sensitivity in diabetic mice. J.Nutr. 140 311 PMID: 20032483

Motani et al (2009) Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo. J.Biol.Chem. 284 7673 PMID: 19147488

If you know of a relevant reference for A 1120, please let us know.

按标靶查看相关产品

关键词: A 1120, A 1120 supplier, A1120, non-retinoid, retinol-binding, proteins, 4, RBP4, ligands, adipokines, transthyretin, TTR, Miscellaneous, Compounds, 3793, Tocris Bioscience

1 篇 A 1120 的引用文献

引用文献是使用了 Tocris 产品的出版物。 A 1120 的部分引用包括：

Du et al (2017) Transgenic Mice Over-Expressing RBP4 Have RBP4-Dependent and Light-Independent Retinal Degeneration. Invest Ophthalmol Vis Sci 58 4375–4383 PMID: 28813718

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