A 350619 hydrochloride

Name: A 350619 hydrochloride
Brand: Tocris Bioscience
SKU: 2753

Cat. No. 2753 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2753 has been discontinued.

View all Guanylyl Cyclases products.

说明： Soluble guanylyl cyclase (sGC) activator

化学名： 3-[2-[(4-Chlorophenyl)thiophenyl]-N-[4-(dimethylamino)butyl]-2-propenamide hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for A 350619 hydrochloride

A 350619 hydrochloride is an activator of soluble guanylyl cyclase (sGC). Activates basal sGC and synergistically activates sGC in the presence of NO. Relaxes cavernosum smooth muscle in vitro and induces penile erections in rats. Induces a sustained increase in skin blood flow in vivo.

技术数据 for A 350619 hydrochloride

分子量	425.41
公式	C₂₁H₂₅ClN₂OS.HCl
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	1217201-17-6
PubChem ID	56924282
InChI Key	PDVBHWZPRQFKJS-KYIGKLDSSA-N
Smiles	O=C(NCCCCN(C)C)/C=C/C1=C(SC2=CC=C(Cl)C=C2)C=CC=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for A 350619 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for A 350619 hydrochloride

参考文献是支持产品生物活性的出版物。

Miller et al (2003) A-350619: a novel activator of soluble guanylyl cyclase. Life Sci. 72 1015 PMID: 12495780

Evgenov et al (2006) NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat.Rev.Drug Discov. 5 755 PMID: 16955067

Kotzki et al (2013) Anodal iontophoresis of a soluble guanylate cyclase stimulator induces a sustained increase in skin blood flow in rats. J.Pharmacol.Exp.Ther. 346 424 PMID: 23838678

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篇 A 350619 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 A 350619 hydrochloride 的引用文献。