Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewA 71915
说明： Highly potent and competitive NPRA antagonist
纯度： ≥95% (HPLC)
生物活性 for A 71915
A 71915 is a highly potent and competitive natriuretic peptide receptor A (NPRA) antagonist (pKi = 9.18). Reduces brain natriuretic peptide (BNP, Cat. No. 3522)-induced scratching in mice.
技术数据 for A 71915
| 分子量 | 1613.95 |
| 公式 | C69H116N26O15S2 |
| 序列 |
RCXGGRIDRIXRC (Modifications: X-3 = Cha, X-11= D-Tic, Cys-13 = C-terminal amide, Disulfide bridge: 2-13) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 132956-87-7 |
| PubChem ID | 25083020 |
| InChI Key | TZQXLCWSYQJGKV-YGLLJKSHSA-N |
| Smiles | CC[C@H](C)[C@@H]1NC(=O)[C@@H](CCCN=C(N)N)NC(=O)CNC(=O)CNC(=O)[C@H](CC2CCCCC2)NC(=O)[C@H](CSS[C@H](CCCN=C(N)N)[C@H](NC(=O)CNC(=O)[C@H]2CC3=CC=CC=C3CN2C(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC1=O)[C@@H](C)CC)C(N)=O)NC(=O)[C@@H](N)CCCN=C(N)N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for A 71915
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for A 71915
参考文献 for A 71915
参考文献是支持产品生物活性的出版物。
Delporte et al (1992) Discovery of a potent atrial natriuretic peptide antagonist for ANPA receptors in the human neuroblastoma NB-OK-1 cell line. Eur.J.Pharmacol. 224 183 PMID: 1334838
Moro et al (2004) Functional and pharmacological characterization of the natriuretic peptide-dependent lipolytic pathway in human fat cells. J.Pharmacol.Exp.Ther. 308 984 PMID: 14634036
Kiguchi et al (2016) Spinal functions of B-type natriuretic peptide, gastrin-releasing peptide, and their cognate receptors for regulating itch in mice. J.Pharmacol.Exp.Ther. 356 596 PMID: 26669425
If you know of a relevant reference for A 71915, please let us know.
按产品操作查看相关产品
关键词: A 71915, A 71915 supplier, A71915, natriuretic, peptide, receptor, NPRA, NPR1, antagonists, antagonism, potent, competitive, Natriuretic, Peptide, Receptor, 6715, Tocris Bioscience
1 篇 A 71915 的引用文献
引用文献是使用了 Tocris 产品的出版物。 A 71915 的部分引用包括：
Hui et al (2022) Atrial Natriuretic Peptide and the Epithelial Sodium Channel Contribute to Spinal Cord Injury-Induced Polyuria in Mice. J Neurotrauma 39 724-734 PMID: 35216518
您是否知道使用了 Tocris A 71915 的优秀论文？ 请告知我们.
A 71915 的评论
目前没有该产品的评论。 Be the first to review A 71915 and earn rewards!
Have you used A 71915?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image