Natriuretic Peptide Receptors
Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl cyclase activity. There are three isoforms of NP receptors; NPR1-3, which have conserved catalytic and regulatory domains and divergent ligand binding domains.
Natriuretic Peptide Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 1912 | Atrial natriuretic factor (1-28) (rat) |
| Endogenous peptide regulating blood pressure | |
| 1906 | Atrial natriuretic factor (1-28) (human, porcine) |
| Endogenous peptide regulating blood pressure | |
| 3522 | Brain natriuretic peptide (1-32) (human) |
| Endogenous peptide agonist at ANP receptor A (NPR1) | |
| 3520 | C-type natriuretic peptide (1-22) (human, rat, swine) |
| Endogenous peptide agonist at NPR2 | |
Natriuretic Peptide Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 6715 | A 71915 |
| Highly potent and competitive NPRA antagonist | |
| 5498 | AP 811 |
| High affinity, selective NPR3 antagonist | |
Natriuretic peptide (NP) receptors are single transmembrane catalytic receptors with intracellular guanylyl cyclase activity. There are three isoforms of NP receptors; NPR1, NPR2 and NPR3, which have conserved catalytic and regulatory domains and divergent ligand binding domains.
Natriuretic peptide receptors bind α-atrial natriuretic peptide, brain natriuretic peptide and type C-natriuretic peptide with varying affinity and are found in the brain, vasculature and kidney. The main physiological role of NP receptors is the homeostasis of body fluid volume.
External sources of pharmacological information for Natriuretic Peptide Receptors :
Natriuretic Peptide Receptor Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| NPR1 | Human | NPR1 | NM_000906 | P16066 |
| Mouse | Npr1 | NM_008727 | P18293 | |
| Rat | Npr1 | NM_012613 | P18910 | |
| NPR2 | Human | NPR2 | NM_003995 | P20594 |
| Mouse | Npr2 | NM_173788 | Q6VVW5 | |
| Rat | Npr2 | NM_053838 | P16067 | |
| NPR3 | Human | NPR3 | NM_000908 | P17342 |
| Mouse | Npr3 | NM_008728 | P70180 | |
| Rat | Npr3 | NM_012868 | P41740 |