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Submit ReviewA 922500
Discontinued Product
3587 has been discontinued.
View all Diacylglycerol <em>O</em>-Acyltransferase products.
说明： Potent DGAT-1 inhibitor
别名： DGAT-1 Inhibitor 4a
化学名： (1R,2R)-2-[[4'-[[Phenylamino)carbonyl]amino] [1,1'-biphenyl]-4-yl]carbonyl]cyclopentanecarboxylic acid
纯度： ≥98% (HPLC)
生物活性 for A 922500
A 922500 is a diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC50 values are 7 and 24 nM at human and mouse DGAT-1 respectively) that is devoid of activity at DGAT-2, ACAT1 or ACAT2. Induces significant weight loss without altering food intake, and decreases liver and plasma triglyceride levels in vivo. Orally active.
技术数据 for A 922500
| 分子量 | 428.48 |
| 公式 | C26H24N2O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 959122-11-3 |
| PubChem ID | 24768261 |
| InChI Key | BOZRFEQDOFSZBV-DHIUTWEWSA-N |
| Smiles | O=[C@]([C@@H]3CCC[C@H]3[C@@](O)=O)C(C=C2)=CC=C2C1=CC=C(NC(NC4=CC=CC=C4)=O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for A 922500
参考文献 for A 922500
参考文献是支持产品生物活性的出版物。
Zhao et al (2008) Validation of diacyl glycerolacyltransferase I as a novel target of obesity and dyslipidemia using a potent and selective small molecule inhibitor. J.Med.Chem. 51 380 PMID: 18183944
King et al (2009) Diacylglycerol acyltransferase 1 inhibition lowers serum triglycerides in the zucker fatty rat and the hyperlipidemic hamster. J.Pharmacol.Exp.Ther. 330 526 PMID: 19478132
King et al (2010) In vivo efficacy of acyl CoA: diacylglycerol acyltransferase (DGAT) 1 inhibition in rodent models of postprandial hyperlipidemia. Eur.J.Pharmacol. 637 155 PMID: 20385122
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关键词: A 922500, A 922500 supplier, Diacylglycerol, acyltransferase, 1, DGAT-1, inhibitors, inhibits, Transferases, A922500, Inhibitor, 4a, O-Acyltransferase, 3587, Tocris Bioscience
4 篇 A 922500 的引用文献
引用文献是使用了 Tocris 产品的出版物。 A 922500 的部分引用包括：
Velliquette et al (2015) Identification of a botanical inhibitor of intestinal diacylglyceride acyltransferase 1 activity via in vitro screening and a parallel, randomized, blinded, placebo-controlled clinical trial. Cell Rep 12 27 PMID: 26246845
Poliakov et al (2012) Origin and evolution of retinoid isomerization machinery in vertebrate visual cycle: hint from jawless vertebrates. PLoS One 7 e49975 PMID: 23209628
Scott et al (2018) TFAP2 transcription factors are regulators of lipid droplet biogenesis. Elife 7 PMID: 30256193
Camus et al (2013) Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core. Nutr Metab (Lond) 288 9915 PMID: 23420847
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