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A 939572

Cat. No. 4845 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent SCD-1 inhibitor
化学名： 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for A 939572

A 939572 is a potent stearoyl-CoA desaturase 1 (SCD1) inhibitor (IC50 = 0.4 nM). Selective for SCD1 over a range of kinases and hERG channels. Inhibits proliferation of squamous cell carcinoma FaDu cells in vitro. Also induces cell death of undifferentiated human embryonic stem cells (ESCs). Orally bioavailable.

化合物库 for A 939572

A 939572 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for A 939572

分子量 387.86
公式 C20H22ClN3O3
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1032229-33-6
PubChem ID 24905400
InChI Key DPYTYQFYDLYWHZ-UHFFFAOYSA-N
Smiles O=C(NC3=CC(C(NC)=O)=CC=C3)N1CCC(OC2=C(Cl)C=CC=C2)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for A 939572

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 38.79 100

制备储备液 for A 939572

以下数据基于产品分子量 387.86。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.58 mL 12.89 mL 25.78 mL
5 mM 0.52 mL 2.58 mL 5.16 mL
10 mM 0.26 mL 1.29 mL 2.58 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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参考文献 for A 939572

参考文献是支持产品生物活性的出版物。

Ben-David et al (2013) Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell 12 167 PMID: 23318055

Xin et al (2008) Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors. Bioorg.Med.Chem.Lett. 18 4298 PMID: 18632269

If you know of a relevant reference for A 939572, please let us know.

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关键词: A 939572, A 939572 supplier, A939572, potent, stearoyl-co1, desaturase, inhibitors, inhibits, SCD1, stem, cells, lipid, metabolism, Stearoyl-CoA, 9-desaturase, ESCs, and, iPSC, 4845, Tocris Bioscience

1 篇 A 939572 的引用文献

引用文献是使用了 Tocris 产品的出版物。 A 939572 的部分引用包括：

Lien et al (2021) Low glycaemic diets alter lipid metabolism to influence tumour growth Nature 599 302 PMID: 34671163

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