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Submit Reviewα,β-Methyleneadenosine 5'-triphosphate trisodium salt is a P2-purinoceptor agonist. Also shown to inhibit adenylate cyclase (Ki = 0.5 mM).
分子量 | 571.15 |
公式 | C11H15N5Na3O12P3 |
储存 | Store at -20°C |
纯度 | ≥98% (HPLC) |
CAS Number | 1343364-54-4 |
PubChem ID | 90488813 |
InChI Key | CBAGKCWFSRTVER-MTQUBGKESA-K |
Smiles | O[C@@H]1[C@@H](COP(CP([O-])(OP([O-])(O)=O)=O)([O-])=O)O[C@@H](N3C2=NC=NC(N)=C2N=C3)[C@@H]1O.[Na+].[Na+].[Na+] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
water | 57.12 | 100 |
以下数据基于产品分子量 571.15。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.75 mL | 8.75 mL | 17.51 mL |
5 mM | 0.35 mL | 1.75 mL | 3.5 mL |
10 mM | 0.18 mL | 0.88 mL | 1.75 mL |
50 mM | 0.04 mL | 0.18 mL | 0.35 mL |
参考文献是支持产品生物活性的出版物。
Krug et al (1973) α,β-Methylene-adenosine 5'-triphosphate. J.Biol.Chem. 248 1203 PMID: 4686923
Burnstock and Kennedy (1985) Is there a basis for distinguishing two types of P2-purinoceptor? Gen.Pharmacol 16 433 PMID: 2996968
If you know of a relevant reference for α,β-Methyleneadenosine 5'-triphosphate trisodium salt, please let us know.
关键词: alpha,beta-Methyleneadenosine 5'-triphosphate trisodium salt, alpha,beta-Methyleneadenosine 5'-triphosphate trisodium salt supplier, P2, agonists, P2-purinoceptor, P2Y, Receptors, Purinergic, P2X, purinoceptors, α, β-Methyleneadenosines, alpha,beta-Methyleneadenosines, 5-triphosphate, trisodium, salt, a,b-Methyleneadenosine, a,b-meATP, 3209, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 α,β-Methyleneadenosine 5'-triphosphate trisodium salt 的部分引用包括:
Palygin et al (2018) Characterization of purinergic receptor expression in ARPKD cystic epithelia. Purinergic Signal 14 485 PMID: 30417216
Haanes and Edvinsson (2014) Expression and characterization of purinergic receptors in rat middle meningeal artery-potential role in migraine. PLoS One 9 e108782 PMID: 25265286
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平均评分: 4 (Based on 1 Review.)
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P2X1 and P2X3 agonist, the product works as expected.