α-CGRP (human)

Name: α -CGRP (human)
Brand: Tocris Bioscience
SKU: 3012
Rating: 5 (1 reviews)

Cat. No. 3012 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： CGRP agonist

纯度： ≥95% (HPLC)

说明书

引用文献

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for α-CGRP (human)

α-CGRP (human) is an endogenous calcitonin gene-related peptide receptor (CGRP) agonist. It is a long-lasting vasodilator. α-CGRP (human) also reduces the secretion of both mouse Ins1 and Ins2 proteins and remodels amylin fibrillization in mouse pancreatic β-cells.

技术数据 for α-CGRP (human)

分子量	3789.33
公式	C₁₆₃H₂₆₇N₅₁O₄₉S₂
序列	ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF (Modifications: Phe-37 = C-terminal amide, Disulfide bridge: 2-7)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	90954-53-3
PubChem ID	44563440
InChI Key	JMJJWZFCOWFIBU-XJVRLEFXSA-N
Smiles	[H]N[C@@H](C)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC1=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for α-CGRP (human)

溶解性	Soluble to 0.50 mg/ml in water

产品说明书 for α-CGRP (human)

分析证书/产品说明书

化学品安全技术说明书

参考文献 for α-CGRP (human)

参考文献是支持产品生物活性的出版物。

Poyner et al (2002) International union of pharmacology XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol.Revs. 54 233

Gray et al (2021) α-CGRP disrupts amylin fibrillization and regulates insulin secretion: implications on diabetes and migraine. Chem.Sci. 12 5853 PMID: 34168810

Kee et al (2018) The role of calcitonin gene related peptide (CGRP) in neurogenic vasodilation and its cardioprotective effects. Front Physiol. 9 1249 PMID: 30283343

If you know of a relevant reference for α-CGRP (human), please let us know.

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关键词: alpha-CGRP (human), alpha-CGRP (human) supplier, CGRP, receptor, agonists, Receptors, calcitonin, amylin, AMY, alpha-CGRP, (human), α-CGRP, a-CGRP, pancreatic, beta-cells, Calcitonin, and, Related, 3012, Tocris Bioscience

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Potent CGRP agonist.

By Anonymous on 09/20/2019

分析类型： In Vitro

种属： Human

细胞系/组织： Hek 293 Cells

in in vitro study (Hek 293 cells), stimulate CGRP Receptor (CLR) on the plasma membrane causing internalization.

Easy to dissolve in DMSO, stock solution concentration 10mM.

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