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Submit Reviewα-Methyl-5-hydroxytryptamine maleate
说明： 5-HT2B agonist
纯度： ≥98% (HPLC)
生物活性
5-HT2B receptor selective agonist with pKi values of 8.4, 6.1 and 7.3 at 5-HT2B, 5-HT2A and 5-HT2C receptors respectively.
技术数据
| 分子量 | 306.32 |
| 公式 | C11H14N2O.C4H4O4 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 97469-12-0 |
| PubChem ID | 9922558 |
| InChI Key | YQNHFSXRABPJLP-BTJKTKAUSA-N |
| Smiles | OC(=O)\C=C/C(O)=O.CC(N)CC1=CNC2=C1C=C(O)C=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书
参考文献
参考文献是支持产品生物活性的出版物。
Baxter et al (1995) 5-HT2 receptor subtypes: a family re-united? TiPS 16 105 PMID: 7792930
Richardson et al (1985) Identification of serotonin M-receptor sub-types and their specific blockade by a new class of drugs. Nature 316 126 PMID: 3839291
Wilson et al (1990) 5-Hydroxytryptamine3 receptors mediate tachycardia in conscious instrumented dogs. J.Pharmacol.Exp.Ther. 252 683 PMID: 1968974
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关键词: alpha-Methyl-5-hydroxytryptamine maleate, alpha-Methyl-5-hydroxytryptamine maleate supplier, 5-HT2B, agonists, Serotonin, Receptors, 5-HT2, α-methyl-5-HT, alpha-methyl-5-HT, a-Me-5-HT, α-Methyl-5-hydroxytryptamine, alpha-Methyl-5-hydroxytryptamine, a-methyl-5-HT, α-Me-5-HT, alpha-Me-5-HT, alphamethyl, αmethyl, amethyl, 0557, Tocris Bioscience
4 篇 α-Methyl-5-hydroxytryptamine maleate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 α-Methyl-5-hydroxytryptamine maleate 的部分引用包括：
Athilingam et al (2017) Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons. Elife 6 PMID: 29206101
Nguyen et al (2019) Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice. Korean J Physiol Pharmacol 23 271 PMID: 31297011
Majeed et al (2016) Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster. Neural Plast 2016 7291438 PMID: 26989517
Coulon et al (2011) Activity Modes in Thalamocortical Relay Neurons are Modulated by G(q)/G(11) Family G-proteins - Serotonergic and Glutamatergic Signaling. Front Cell Neurosci 4 132 PMID: 21267426
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.