5-HT2B Receptors
Serotonin 5-HT2B receptors, previously known as 5-HT2F receptors, are located primarily in the stomach fundus, uterus, vascular endothelial and vascular and GI smooth muscle, with limited distribution in the brain. 5-HT2B overexpression leads to ventricular hypertrophy.
5-HT2B Receptor Antagonists |
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|---|---|
| Cat. No. | Product Name / Activity |
| 4081 | LY 266097 hydrochloride |
| Selective 5-HT2B antagonist | |
| 3077 | LY 272015 hydrochloride |
| High affinity 5-HT2B antagonist; orally active | |
| 2993 | RS 127445 hydrochloride |
| High affinity and selective 5-HT2B antagonist | |
| 1372 | SB 204741 |
| Potent, selective 5-HT2B antagonist | |
| 1661 | SB 206553 hydrochloride |
| Potent and selective 5-HT2B and 5-HT2C antagonist; orally active | |
Ligands |
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| Cat. No. | Product Name / Activity |
| 7953 | CELT-211 |
| Fluorescent serotonin 5HT2B receptor ligand for HTS | |
Serotonin 5-HT2B receptors, previously known as 5-HT2F receptors, are located primarily in the stomach fundus, uterus, vascular endothelial and vascular and GI smooth muscle, with limited distribution in the brain. The functions of 5-HT2B receptors include regulation of differentiation and proliferation of the embryonic and adult heart, gastrointestinal contraction and endothelium-dependent relaxation. Furthermore, 5-HT2B receptor knockout mice exhibit gross heart defects and 5-HT2B overexpression leads to ventricular hypertrophy. The human 5-HT2B receptor gene has been localized to chromosome 2 (2q36.3-q37.1).
External sources of pharmacological information for 5-HT2B Receptors :
Literature for 5-HT2B Receptors
Tocris offers the following scientific literature for 5-HT2B Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Our 5-HT review summarizes the serotonin receptor subtypes and highlights their importance in mediating various physiological & pharmacological processes.
Request copyRequest PDFWritten by P. Skolnich et al
Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder.
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