α-MSH

Pricing Availability   Qty
说明: Endogenous melanocortin receptor agonist
别名: α-Melanotropin,α-Melanocyte-stimulating hormone
纯度: ≥95% (HPLC)
说明书
引用文献 (2)
评论
文献 (1)

生物活性 for α-MSH

α-MSH is an endogenous melanocortin receptor agonist (Ki values are 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-inflammatory cytokine IL-10. Inhibits food intake and induces penile erections following i.c.v. administration.

技术数据 for α-MSH

分子量 1664.9
公式 C77H109N21O19S
序列 SYSMEHFRWGKPV

(Modifications: Ser-1 = N-terminal Ac, Val-13 = C-terminal amide)

储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 581-05-5
PubChem ID 16132144
InChI Key WHNFPRLDDSXQCL-UAZQEYIDSA-N
Smiles CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for α-MSH

溶解性 Soluble to 0.60 mg/ml in water

产品说明书 for α-MSH

分析证书/产品说明书
选择另一批次:

参考文献 for α-MSH

参考文献是支持产品生物活性的出版物。

Wikber (1999) Melanocortin receptors: perspectives for novel drugs. Eur.J.Pharmacol. 375 295 PMID: 10443584

Mizusawa et al (2002) Alpha-melanocyte stimulating hormone and oxyt. induced penile erections, and intracavernous pressure increases in the rat. J.Urol. 167 757 PMID: 11792967

Yamaoka-Tojo et al (2006) Central neurotranspeptide, alpha-melanocyte-stimulating hormone (α-MSH) is upregulated in patients with congestive heart failure. Intern.Med. 45 429 PMID: 16679696


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查看全部 Melanocortin (MC) Receptor Agonists

关键词: alpha-MSH, alpha-MSH supplier, Endogenous, melanocortin, receptor, agonists, MC, Receptors, Melanocortin, α-MSH, alpha-MSH, α-Melanocyte-stimulating, alpha-Melanocyte-stimulating, hormone, α-Melanotropin, alpha-Melanotropin, a-MSH, a-Melanotropin, a-Melanocyte-stimulating, 2584, Tocris Bioscience

2 篇 α-MSH 的引用文献

引用文献是使用了 Tocris 产品的出版物。 α-MSH 的部分引用包括:

Nepomuceno et al (2018) Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro. Front Pharmacol 9 157 PMID: 29599718

Nøhr et al (2017) The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. Neurochem Int 102 105 PMID: 27916541


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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。


Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.