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α-Spinasterol

Cat. No. 4729 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4729 has been discontinued.

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说明： TRPV1 antagonist; active in vivo
化学名： (3β,5α,22E)-Stigmasta-7.22-dien-3-ol
纯度： ≥95% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for α-Spinasterol

α-Spinasterol is a TRPV1 antagonist (IC50 = 1.4 μM). Reduces capsaicin-mediated Ca2+ influx in vitro; displays antinociceptive and antiedematogenic effects in multiple mouse models of pain. Brain penetrant and orally bioavailable.

技术数据 for α-Spinasterol

分子量 412.69
公式 C29H48O
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 481-18-5
PubChem ID 5281331
InChI Key JZVFJDZBLUFKCA-FXIAWGAOSA-N
Smiles C[C@H](/C=C/[C@@H](CC)C(C)C)[C@@]4([H])CC[C@@]3([H])C2=CC[C@@]1([H])C[C@@H](O)CC[C@@](C)1[C@]([H])2CC[C@@]34C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for α-Spinasterol

参考文献是支持产品生物活性的出版物。

Trevisan et al (2012) Identification of the plant steroid α-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties. J.Pharmacol.Exp.Ther. 343 258 PMID: 22837009

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关键词: alpha-Spinasterol, alpha-Spinasterol supplier, alpha-Spinasterol, α-Spinasterol, antinociceptives, TRPV1, blockers, antagonists, blocks, inhibits, antiedematogenics, in, vivo, brain, penetrant, orally, bioavailable, TRPV, 4729, Tocris Bioscience

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