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α-Synuclein Degrader 2b

Cat. No. 8040 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： α-synuclein Degrader (PROTAC®)
化学名： 2-[[3-[5-(1,3-Benzodioxol-5-yl)-1H-pyrazol-3-yl]phenyl]amino]-N-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]acetamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for α-Synuclein Degrader 2b

α-Synuclein Degrader 2b is a selective α-synuclein Degrader (PROTAC®) (DC50 = 7.5 μM; Dmax = 89%). Comprises the probe molecule sery308, joined by a linker to a pomalidomide E3 ligase ligand. Activates both proteasomal and lysosomal degradation pathways. Protects SH-SY5Y cells from α-synuclein-induced cytotoxicity. Cell permeable.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

技术数据 for α-Synuclein Degrader 2b

分子量 767.8
公式 C39H41N7O10
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2781922-42-5
InChI Key IYFKRANQUJUTKF-UHFFFAOYSA-N
Smiles O=C(CNC1=CC=CC(C2=NNC(C3=CC4=C(OCO4)C=C3)=C2)=C1)NCCOCCOCCOCCNC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for α-Synuclein Degrader 2b

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 76.78 100

制备储备液 for α-Synuclein Degrader 2b

以下数据基于产品分子量 767.8。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.3 mL 6.51 mL 13.02 mL
5 mM 0.26 mL 1.3 mL 2.6 mL
10 mM 0.13 mL 0.65 mL 1.3 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

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产品说明书 for α-Synuclein Degrader 2b

分析证书/产品说明书
化学品安全技术说明书

参考文献 for α-Synuclein Degrader 2b

参考文献是支持产品生物活性的出版物。

Tong et al (2023) Discovery of small-molecule degraders for alpha-synuclein aggregates. J.Med.Chem. 66 7926 PMID: 37267712

If you know of a relevant reference for α-Synuclein Degrader 2b, please let us know.

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关键词: a-Synuclein Degrader 2b, a-Synuclein Degrader 2b supplier, alpha, synuclein, degrader, 2b, degraders, a-Synuclein, proteolysis, targeting, chimera, PROTAC, degradation, tpd, E3, ligase, cereblon, neuroscience, parkinson, parkinsons, Other, Degraders, 8040, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia