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hCAII Degrader 11

Cat. No. 7964 Submit a Review Datasheet / COA / SDS
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Description: Potent human carbonic anhydrase II Degrader (PROTAC®)
Chemical Name: 4-(Aminosulfonyl)-N-[12-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]dodecyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for hCAII Degrader 11

hCAII Degrader 11 is a potent human carbonic anhydrase II (hCAII) Degrader (PROTAC®; Dmax = 100% at 5 nM, DC50 = 0.5 nM).

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Sold with kind permission of Professor Cohen and Professor Burkart, Department of Chemistry and Biochemistry, University of California, USA.

Licensing Information

Sold with kind permission of Professor Cohen and Professor Burkart

Technical Data for hCAII Degrader 11

M. Wt 639.77
Formula C32H41N5O7S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2892306-56-6
PubChem ID 167312395
InChI Key AZBRPAQQOMDJLZ-UHFFFAOYSA-N
Smiles O=C(NCCCCCCCCCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)C4=CC=C(S(=O)(N)=O)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for hCAII Degrader 11

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 63.98 100

Preparing Stock Solutions for hCAII Degrader 11

The following data is based on the product molecular weight 639.77. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.56 mL 7.82 mL 15.63 mL
5 mM 0.31 mL 1.56 mL 3.13 mL
10 mM 0.16 mL 0.78 mL 1.56 mL
50 mM 0.03 mL 0.16 mL 0.31 mL

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Reconstitution Calculator

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Product Datasheets for hCAII Degrader 11

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for hCAII Degrader 11

References are publications that support the biological activity of the product.

O'Herin et al (2023) Development of human carbonic anhydrase II heterobifunctional degraders J.Med.Chem. 66 2789 PMID: 36735827

If you know of a relevant reference for hCAII Degrader 11, please let us know.

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Citations for hCAII Degrader 11

Citations are publications that use Tocris products.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia