α-Synuclein Degrader 2bn

Cat. No. 8041 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Negative control for α Synuclein Degrader 2b (Cat. No. 8040)

化学名： 2-[[3-[5-(1,3-Benzodioxol-5-yl)-1H-pyrazol-3-yl]phenyl]amino]-N-[2-[2-[2-[2-[[2-(1-methyl-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]acetamide

纯度： ≥98% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for α-Synuclein Degrader 2bn

α-Synuclein Degrader 2bn is the negative control for α-Synuclein Degrader 2b (Cat. No. 8040).

技术数据 for α-Synuclein Degrader 2bn

分子量	781.82
公式	C₄₀H₄₃N₇O₁₀
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	3034069-88-7
InChI Key	FMDSDFONWFBVFG-UHFFFAOYSA-N
Smiles	O=C(CNC1=CC=CC(C2=NNC(C3=CC4=C(OCO4)C=C3)=C2)=C1)NCCOCCOCCOCCNC5=CC=CC(C(N6C7C(N(C)C(CC7)=O)=O)=O)=C5C6=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for α-Synuclein Degrader 2bn

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	78.18	100

制备储备液 for α-Synuclein Degrader 2bn

以下数据基于产品分子量 781.82。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.28 mL	6.4 mL	12.79 mL
5 mM	0.26 mL	1.28 mL	2.56 mL
10 mM	0.13 mL	0.64 mL	1.28 mL
50 mM	0.03 mL	0.13 mL	0.26 mL

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产品说明书 for α-Synuclein Degrader 2bn

分析证书/产品说明书

化学品安全技术说明书

参考文献 for α-Synuclein Degrader 2bn

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TPD and Induced Proximity Research Product GuideUpdated

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

Active Degraders
TAG Degradation Platform
Degrader Building Blocks
Assays for Protein Degradation
Induced Proximity Tools

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia