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α-Synuclein Degrader 2b

Cat. No. 8040 Submit a Review Datasheet / COA / SDS
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Description: α-synuclein Degrader (PROTAC®)
Chemical Name: 2-[[3-[5-(1,3-Benzodioxol-5-yl)-1H-pyrazol-3-yl]phenyl]amino]-N-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for α-Synuclein Degrader 2b

α-Synuclein Degrader 2b is a selective α-synuclein Degrader (PROTAC®) (DC50 = 7.5 μM; Dmax = 89%). Comprises the probe molecule sery308, joined by a linker to a pomalidomide E3 ligase ligand. Activates both proteasomal and lysosomal degradation pathways. Protects SH-SY5Y cells from α-synuclein-induced cytotoxicity. Cell permeable.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for α-Synuclein Degrader 2b

M. Wt 767.8
Formula C39H41N7O10
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2781922-42-5
InChI Key IYFKRANQUJUTKF-UHFFFAOYSA-N
Smiles O=C(CNC1=CC=CC(C2=NNC(C3=CC4=C(OCO4)C=C3)=C2)=C1)NCCOCCOCCOCCNC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for α-Synuclein Degrader 2b

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 76.78 100

Preparing Stock Solutions for α-Synuclein Degrader 2b

The following data is based on the product molecular weight 767.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.3 mL 6.51 mL 13.02 mL
5 mM 0.26 mL 1.3 mL 2.6 mL
10 mM 0.13 mL 0.65 mL 1.3 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Product Datasheets for α-Synuclein Degrader 2b

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for α-Synuclein Degrader 2b

References are publications that support the biological activity of the product.

Tong et al (2023) Discovery of small-molecule degraders for alpha-synuclein aggregates. J.Med.Chem. 66 7926 PMID: 37267712

If you know of a relevant reference for α-Synuclein Degrader 2b, please let us know.

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Citations for α-Synuclein Degrader 2b

Citations are publications that use Tocris products.

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Literature in this Area

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia