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A37

Cat. No. 5802 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： ALDH1A1 inhibitor
别名： CM 037
化学名： Ethyl 2-[[3,4-dihydro-4-oxo-3-[3-(1-pyrrolidinyl)propyl][1]benzothieno[3,2-d]pyrimidin-2-yl]thio]acetate
纯度： ≥97% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for A37

A37 is an ALDH1A1 inhibitor (IC50 = 4.6 μM; Ki = 300 nM). Exhibits selectivity for ALDH1A1 over eight other ALDH isoforms. Disrupts spheroid formation and reduces cell viability of ovarian cancer cells in vitro.

化合物库 for A37

A37 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for A37

分子量 431.57
公式 C21H25N3O3S2
储存 Store at +4°C
纯度 ≥97% (HPLC)
CAS Number 896795-60-1
PubChem ID 5049161
InChI Key SKDRHRAYBYQVNU-UHFFFAOYSA-N
Smiles O=C1N(CCCN2CCCC2)C(SCC(OCC)=O)=NC3=C1SC4=C3C=CC=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for A37

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 43.16 100
ethanol 43.16 100

制备储备液 for A37

以下数据基于产品分子量 431.57。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.59 mL 23.17 mL
5 mM 0.46 mL 2.32 mL 4.63 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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参考文献 for A37

参考文献是支持产品生物活性的出版物。

Morgan and Hurley (2015) Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors. J.Med.Chem 58 1964 PMID: 25634381

Condello et al (2015) β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids. Oncogene 34 2297 PMID: 24954508

If you know of a relevant reference for A37, please let us know.

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关键词: A37, A37 supplier, Aldehyde, dehydrogenase-1A1, ALDH1A1, inhibitors, inhibits, CM037, CM, 037, Dehydrogenase, Cancer, Stem, Cells, 5802, Tocris Bioscience

1 篇 A37 的引用文献

引用文献是使用了 Tocris 产品的出版物。 A37 的部分引用包括：

Rui et al (2020) Phenotypic landscape of intestinal organoid regeneration. Nature 586 275-280 PMID: 33029001

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