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Submit ReviewAA 2414 is a thromboxane A2 (TP) receptor antagonist. Antiasthmatic agent; inhibits platelet aggregation and bronchoconstriction induced by a TXA2 mimetic in guinea pigs.
分子量 | 354.44 |
公式 | C22H26O4 |
储存 | Store at +4°C |
纯度 | ≥98% (HPLC) |
CAS Number | 112665-43-7 |
PubChem ID | 2449 |
InChI Key | ZBVKEHDGYSLCCC-UHFFFAOYSA-N |
Smiles | O=C1C(C)=C(C)C(C(C(C2=CC=CC=C2)CCCCCC(O)=O)=C1C)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Ashida et al (1989) A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. Prostaglandins 38 91 PMID: 2748922
Kurokawa et al (1994) Antagonism of the human thromboxane A2 receptor by an anti-asthmatic agent AA-2414. Biol.Pharm.Bull. 17 383 PMID: 8019502
Cui et al (2007) Leukotrienes and cyclooxygenase products mediate anaphylactic venoconstriction in ovalbumin sensitized rat livers. Eur.J.Pharmacol. 576 99 PMID: 17706964
关键词: AA 2414, AA 2414 supplier, Thromboxane, A2, TP, receptors, antagonists, TXA2, Prostanoid, prostaglandins, prostacyclins, eicosanoids, AA2414, Seratrodast, Receptors, 3025, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 AA 2414 的部分引用包括:
Hennenberg et al (2013) The receptor antagonist picotamide inhibits adrenergic and thromboxane-induced contraction of hyperplastic human prostate smooth muscle. Am J Physiol Renal Physiol 305 F1383 PMID: 24049147
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