Abiraterone acetate

Cat. No. 6520 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent CYP17A1 inhibitor

化学名： (3β)-17-(3-Pyridinyl)androsta-5,16-dien-3-yl acetate

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Abiraterone acetate

Abiraterone acetate is a potent CYP17A1 inhibitor (IC₅₀ values are 17 nM and 18 nM for 17,20-lyase activity and 17α-hydroxylase activity, respectively). Inhibits intratumor androgen synthesis in prostate cancer.

化合物库 for Abiraterone acetate

Abiraterone acetate is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Abiraterone acetate

分子量	391.55
公式	C₂₆H₃₃NO₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	154229-18-2
PubChem ID	9821849
InChI Key	UVIQSJCZCSLXRZ-UBUQANBQSA-N
Smiles	[H][C@@]12CC=C([C@]1(CC[C@]3([C@]2(CC=C4C[C@@H](OC(C)=O)CC[C@]34C)[H])[H])C)C5=CN=CC=C5

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Abiraterone acetate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	7.83	20
	ethanol	39.16	100

制备储备液 for Abiraterone acetate

以下数据基于产品分子量 391.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.55 mL	12.77 mL	25.54 mL
5 mM	0.51 mL	2.55 mL	5.11 mL
10 mM	0.26 mL	1.28 mL	2.55 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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产品说明书 for Abiraterone acetate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Abiraterone acetate

参考文献是支持产品生物活性的出版物。

Potter et al (1995) Novel steroidal inhibitors of human cytochrome P450_17α (l7α-Hydroxylase-C_l7,20-lyase): potential agents for the treatment of prostatic cancer. J.Med.Chem. 38 2463 PMID: 7608911

Barrie et al (1994) Pharmacology of novel steroidal inhibitors of cytochrome P450(17) alpha (17 alpha-hydroxylase/C17-20 lyase). J.Steroid Biochem.Mol.Biol. 50 267 PMID: 7918112

If you know of a relevant reference for Abiraterone acetate, please let us know.

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关键词: Abiraterone acetate, Abiraterone acetate supplier, Potent, cytochrome, P450, CYP17A1, inhibitors, inhibits, CYP450c17, 17,20-lyase, 17alpha-hydroxylase, androgen, synthesis, prostate, cancer, Cytochrome, 6520, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Abiraterone acetate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

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