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Submit ReviewAbn-CBD
说明： Selective GPR55 agonist; neurobehaviorally inactive
别名： Abnormal-cannabidiol
化学名： 4-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol
纯度： ≥97% (HPLC)
生物活性 for Abn-CBD
Abn-CBD is a neurobehaviorally inactive cannabinoid that acts as a selective agonist for GPR55 (EC50 values are 2.5, >30 and >30 μM at GPR55, CB1 and CB2 receptors respectively). Increases phosphorylation of protein kinases in, and migration of, human umbilical vein endothelial cells.
技术数据 for Abn-CBD
| 分子量 | 314.47 |
| 公式 | C21H30O2 |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 22972-55-0 |
| PubChem ID | 89949 |
| InChI Key | YWEZXUNAYVCODW-RBUKOAKNSA-N |
| Smiles | C=[C@](C)[C@@H]1CCC(C)=C[C@H]1[C@]2=C(O)C=C(O)C=C2CCCCC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Abn-CBD
参考文献 for Abn-CBD
参考文献是支持产品生物活性的出版物。
Ho and Hiley (2003) Vasodilator actions of abnormal-cannabidiol in rat isolated small mesenteric artery. Br.J.Pharmacol. 138 1320 PMID: 12711633
Jarai et al (1999) Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Proc.Natl.Acad.Sci.U.S.A. 96 14136 PMID: 10570211
Mo et al (2004) Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1. Eur.J.Pharmacol. 489 21 PMID: 15063151
Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092 PMID: 17876302
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关键词: Abn-CBD, Abn-CBD supplier, Selective, GPR55, agonists, neurobehaviorally, inactive, cannabinoids, receptors, cannabidiol, Abnormal-cannabidiol, 1297, Tocris Bioscience
3 篇 Abn-CBD 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Abn-CBD 的部分引用包括：
Hao et al (2015) Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis. Cell Death Dis 21 38 PMID: 25569804
Esposito et al (2007) Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression. Br J Pharmacol 151 1272 PMID: 17592514
Yang et al (2014) Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy. Free Radic Biol Med 68 260 PMID: 24398069
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.