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Submit ReviewABT 594 hydrochloride
说明： Selective α4β2 nAChR agonist
别名： Tebanicline
化学名： (R)-5-(Azetidin-2-ylmethoxy)-2-chloropyridine hydrochloride
纯度： ≥98% (HPLC)
生物活性 for ABT 594 hydrochloride
ABT 594 hydrochloride is a selective α4β2 nAChR agonist (EC50 = 140 nM for human α4β2 nAChRs, in vitro). Exhibits >900-fold selectivity for α4β2 nAChRs over other neurotransmitter receptors. Displays analgesic properties in various animal models of pain. Potentiates gabapentin mediated analgesia. Also demonstrates cognitive enhancement effects in rodent model of attention deficit.
化合物库 for ABT 594 hydrochloride
ABT 594 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for ABT 594 hydrochloride
| 分子量 | 235.11 |
| 公式 | C9H11ClN2O.HCL |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 203564-54-9 |
| PubChem ID | 72193963 |
| InChI Key | GYVARJONEFSAJB-OGFXRTJISA-N |
| Smiles | ClC1=NC=C(C=C1)OC[C@H]2CCN2.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for ABT 594 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 23.51 | 100 | |
| DMSO | 23.51 | 100 |
制备储备液 for ABT 594 hydrochloride
以下数据基于产品分子量 235.11。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.25 mL | 21.27 mL | 42.53 mL |
| 5 mM | 0.85 mL | 4.25 mL | 8.51 mL |
| 10 mM | 0.43 mL | 2.13 mL | 4.25 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.85 mL |
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产品说明书 for ABT 594 hydrochloride
参考文献 for ABT 594 hydrochloride
参考文献是支持产品生物活性的出版物。
Donnelly-Roberts et al (1998) ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization. J.Pharmacol.Exp.Ther. 285 777 PMID: 9580626
Lynch et al (2005) ABT-594 (a nicotinic acetylcholine agonist): anti-allodynia in a rat chemotherapy-induced pain model. Eur.J.Pharmacol. 509 43 PMID: 15713428
Munro et al (2010) Selective potentiation of gabapentin-mediated antinociception in the rat formalin test by the nicotinic acetylcholine receptor agonist ABT-594. Neuropharmacology 59 208 PMID: 20562022
Mar et al (2017) MAM-E17 rat model impairments on a novel continuous performance task: effects of potential cognitive enhancing drugs. Psychopharmacology (Berl) 234 2837 PMID: 28744563
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
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