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Submit ReviewABT 724 trihydrochloride
说明： Potent and selective D4 partial agonist; proerectile
化学名： 2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole trihydrochloride
纯度： ≥99% (HPLC)
生物活性 for ABT 724 trihydrochloride
ABT 724 trihydrochloride is an ABT 724 is a potent dopamine D4 receptor partial agonist (EC50 = 12.4 nM; 61% efficacy vs. dopamine), which displays no agonist activity at D2 receptors (EC50 > 10 μM). ABT 724 is selective in rats in vivo and produces penile erection following i.c.v. administration, and increases intracavernosal pressure and potentiates the proerectile effects of sildenafil following s.c. administration. This compound displays minimal side effects.
External Portal information for ABT 724 trihydrochloride
The Chemical Probes webpages of the Structural Genomics Consortium are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of ABT 724 is reviewed on the chemical probes website.
技术数据 for ABT 724 trihydrochloride
| 分子量 | 402.75 |
| 公式 | C17H19N5.3HCl |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 587870-77-7 |
| PubChem ID | 16759165 |
| InChI Key | AZFUVPBLKQGSRI-UHFFFAOYSA-N |
| Smiles | Cl.Cl.Cl.C(N1CCN(CC1)C1=NC=CC=C1)C1=NC2=CC=CC=C2N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ABT 724 trihydrochloride
参考文献 for ABT 724 trihydrochloride
参考文献是支持产品生物活性的出版物。
Stewart et al (2004) DA D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning. J.Med.Chem. 47 2348 PMID: 15084133
Cowart et al (2004) Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a DArgic agent with a novel mode of action for the potential treatment of erectile dysfunction. J.Med.Chem. 47 3853 PMID: 15239663
Brioni et al (2004) Activation of DA D4 receptors by ABT-724 induces penile erection in rats. Proc.Natl.Acad.Sci.USA 101 6758
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关键词: ABT 724 trihydrochloride, ABT 724 trihydrochloride supplier, Potent, selective, D4, partial, agonists, proerectile, Dopamine, Receptors, dopaminergic, ABT724, trihydrochloride, 2214, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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