AC 186

Cat. No. 5053 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective ERβ agonist; neuroprotective

化学名： 4-[4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl]phenol

纯度： ≥99% (HPLC)

引用文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for AC 186

AC 186 is a potent and selective ERβ agonist (EC₅₀ values are 6 and 5000 nM for ERβ and ERα respectively). Exhibits gender selective neuroprotective effects in a male rat model of Parkinson's disease. Decreases Aβ levels in combination with ACP-105 in a rat model of Alzheimer's disease.

化合物库 for AC 186

AC 186 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for AC 186

分子量	306.32
公式	C₁₈H₁₇F₃O
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	1421854-16-1
PubChem ID	71245042
InChI Key	HSMUKSLNDJOZQG-UHFFFAOYSA-N
Smiles	FC1(F)CCC(C2=C(F)C=CC=C2)(C3=CC=C(O)C=C3)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AC 186

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	30.63	100

制备储备液 for AC 186

以下数据基于产品分子量 306.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.26 mL	16.32 mL	32.65 mL
5 mM	0.65 mL	3.26 mL	6.53 mL
10 mM	0.33 mL	1.63 mL	3.26 mL
50 mM	0.07 mL	0.33 mL	0.65 mL

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产品说明书 for AC 186

分析证书/产品说明书

化学品安全技术说明书

参考文献 for AC 186

参考文献是支持产品生物活性的出版物。

George et al (2013) Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease. ACS Chem.Neurosci. 4 1537 PMID: 24020966

McFarland et al (2013) AC-186, a selective nonsteroidal estrogen receptor β agonist, shows gender specific neuroprotection in a Parkinson's disease rat model. ACS Chem.Neurosci. 4 1249 PMID: 23898966

If you know of a relevant reference for AC 186, please let us know.

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1 篇 AC 186 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AC 186 的部分引用包括：

Hanna S et al (2022) Activity of Estrogen Receptor β Agonists in Therapy-Resistant Estrogen Receptor-Positive Breast Cancer. Front Oncol 12 857590 PMID: 35574319

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Pathways for AC 186

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.