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说明： Potent and selective amylin antagonist
纯度： ≥95% (HPLC)
生物活性 for AC 187
AC 187 is an orally active, potent amylin receptor antagonist (IC50 = 0.48 nM) that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. Blocks amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. Increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo.
技术数据 for AC 187
| 分子量 | 2890.25 |
| 公式 | C127H205N37O40 |
| 序列 |
VLGKLSQELHKLQTYPRTNTGSNTY (Modifications: Val-1 = N-terminal Ac, Tyr-25 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 151804-77-2 |
| PubChem ID | 16133792 |
| InChI Key | ZLFXHYNEZYAYPG-AABHONRUSA-N |
| Smiles | CC(C)C[C@H](NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for AC 187
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for AC 187
参考文献 for AC 187
参考文献是支持产品生物活性的出版物。
Jhamandas and MacTavish (2004) Antagonist of the amylin receptor blocks β-amyloid toxicity in rat cholinergic basal forebrain neurons. J.Neurosci. 24 5579 PMID: 15201330
Gedulin et al (2006) Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187. Regul.Pept. 137 121 PMID: 16914214
Reidelberger et al (2004) Amylin receptor blockade stimulates food intake in rats. Am.J.Physiol.Inter.Comp.Physiol. 287 R568 PMID: 15130879
If you know of a relevant reference for AC 187, please let us know.
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关键词: AC 187, AC 187 supplier, Potent, selective, amylin, receptors, antagonists, AC187, Calcitonin, and, Related, Receptors, 3419, Tocris Bioscience
3 篇 AC 187 的引用文献
引用文献是使用了 Tocris 产品的出版物。 AC 187 的部分引用包括：
Baisley et al (2014) Antipsychotic-like actions of the satiety peptide, amylin, in ventral striatal regions marked by overlapping calcitonin receptor and RAMP-1 gene expression. J Neurosci 34 4318 PMID: 24647952
Nuñez-Diaz et al (2023) Contraction of human brain vascular pericytes in response to islet amyloid polypeptide is reversed by pramlintide. Mol Brain 16 25 PMID: 36793056
Liberini et al (2016) The satiating hormone amylin enhances neurogenesis in the area postrema of adult rats. Mol Metab 5 834 PMID: 27688997
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.