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AC 1903

Cat. No. 6766 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective TRPC5 inhibitor
化学名： N-(2-Furanylmethyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AC 1903

AC 1903 is a selective TRPC5 blocker (IC50 = 4.0 - 13.6 μM). Also displays weak inhibition at TRPC4 (IC50 >100 μM) but not TRPC6. Exhibits no effect against a standard panel of profiling kinases. Blocks TRPC5 channel activity in glomeruli of proteinuric rats. Suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of focal segmental glomerulosclerosis (FSGS).

化合物库 for AC 1903

AC 1903 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for AC 1903

分子量 303.36
公式 C19H17N3O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 831234-13-0
PubChem ID 667146
InChI Key OECUWHDVQIITIS-UHFFFAOYSA-N
Smiles C1(NCC2=CC=CO2)=NC3=CC=CC=C3N1CC4=CC=CC=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AC 1903

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 15.17 50

制备储备液 for AC 1903

以下数据基于产品分子量 303.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 6.59 mL 32.96 mL 65.93 mL
2.5 mM 1.32 mL 6.59 mL 13.19 mL
5 mM 0.66 mL 3.3 mL 6.59 mL
25 mM 0.13 mL 0.66 mL 1.32 mL

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参考文献 for AC 1903

参考文献是支持产品生物活性的出版物。

Chung et al (2017) TRP'ing up chronic kidney disease. Science 358 1256 PMID: 29217557

Zhou et al (2017) A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Science 358 1332 PMID: 29217578

Minard et al (2018) Remarkable progress with small-molecule modulation of TRPC1/4/5 channels: implications for understanding the channels in health and disease. Cells 7 doi: 10.3390 PMID: 29865154

Sharma et al (2019) Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903. Bioorg.Med.Chem.Lett. 29 155 PMID: 30538066

If you know of a relevant reference for AC 1903, please let us know.

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关键词: AC 1903, AC 1903 supplier, AC1903, selective, TRPC5, blockers, blocks, proteinuria, TRPC, 6766, Tocris Bioscience

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