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Submit ReviewAC 253
Discontinued Product
6550 has been discontinued.
View all Calcitonin and Related Receptors products.
说明： Amylin (AMY3) antagonist
生物活性 for AC 253
AC 253 is an amylin (AMY3) receptor antagonist. Inhibits andrenomedulin-stimulated cAMP production in vitro. Protects against oligomeric Aβ-induced increase in intracellular Ca2+, activation of PKA, MAPK, Akt and cFOS and cell death in neuronal cell culture. Blocks electrophysiological effects of Aβ in vitro. Cyclic AC 253 (Cat.No. 6550) also available.
技术数据 for AC 253
| 分子量 | 2847.11 |
| 公式 | C122H196N40O39 |
| 序列 |
LGRLSQELHRLQTYPRTNTGSNTY (Modifications: Leu-1 = N-terminal Ac, Tyr-24 = C-terminal amide) |
| 储存 | Store at -20°C |
| CAS Number | 151804-79-4 |
| PubChem ID | 134160251 |
| InChI Key | QOVDFCPGVUGNIP-MLZIZKOLSA-N |
| Smiles | CC(C)C[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AC 253
参考文献 for AC 253
参考文献是支持产品生物活性的出版物。
Coppock et al (1999) Rat-2 fibroblasts express specific adrenomedullin receptors, but not calcitonin-gene-related-peptide receptors, which mediate increased intracellular cAMP and inhibit mitogen-activated protein kinase activity. Biochem.J. 338 15 PMID: 9931292
Jhamandas et al (2011) Actions of β-amyloid protein on human neurons are expressed through the amylin receptor. Am.J.Pathol. 178 140 PMID: 21224052
Fu et al (2012) Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways. J,Biol.Chem. 287 18820 PMID: 22500019
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关键词: AC 253, AC 253 supplier, AC253, amylin, receptor, antagonists, antagonism, neuroprotective, Abeta, amyloid, beta, AB, Aβ, Calcitonin, and, Related, Receptors, Amyloid, Beta, Peptides, 6550, Tocris Bioscience
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Peptides Involved in Appetite Modulation Scientific Review
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